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A naturally occurring SNP modulates thermotolerance divergence among grapevines

Author

Listed:
  • Haiyang Chen

    (The Chinese Academy of Sciences
    China National Botanical Garden
    Henan Agricultural University
    University of Chinese Academy of Sciences)

  • Haibo Yu

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Ling Yuan

    (Lexington)

  • Lingchao Kong

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Shenchang Li

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Xiongjun Cao

    (Guangxi Academy of Agricultural Sciences)

  • Yang Li

    (The Chinese Academy of Sciences
    China National Botanical Garden)

  • Yi Wang

    (The Chinese Academy of Sciences
    China National Botanical Garden)

  • Ling Lin

    (Guangxi Academy of Agricultural Sciences)

  • Rongrong Guo

    (Guangxi Academy of Agricultural Sciences)

  • Taili Xie

    (Guangxi Academy of Agricultural Sciences)

  • Wei Duan

    (The Chinese Academy of Sciences
    China National Botanical Garden)

  • Zhanwu Dai

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Peige Fan

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Shaohua Li

    (The Chinese Academy of Sciences
    China National Botanical Garden)

  • Zhenchang Liang

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

  • Lijun Wang

    (The Chinese Academy of Sciences
    China National Botanical Garden
    University of Chinese Academy of Sciences)

Abstract

With the increasing challenges posed by global warming and climate change, heat stress has become a significant threat to the sustainable production of grapevines. However, the genetic basis of grapevine thermotolerance remains poorly understood. Here, we combine genome-wide association study with transcriptomic profiling to identify TTC4 (thermotolerance on chromosome 4), a gene encoding a WRKY transcription factor, as a key determinant of thermotolerance in grapevine. TTC4 directly activates two thermotolerance-related genes, HSP18.1 and APX3. We also identify a heat-suppressed repressor SPL13 (SQUAMOSA-promoter binding protein-like 13) that cannot bind to the GTAT element (TTC4T(7631)) in intron 2 of TTC4, but can bind to the natural variant, GTAC (TTC4C(7631)). Grapevine accessions with TTC4C/C(7631) genotype exhibit significantly lower thermotolerance compared to those with the TTC4T/T(7631) and TTC4C/T(7631) genotypes. This fine-tuned regulation contributes to thermotolerance divergence among grapevine populations. The TTC4T(7631) haplotype holds significant potential as a genetic resource for breeding thermotolerant grapevine varieties.

Suggested Citation

  • Haiyang Chen & Haibo Yu & Ling Yuan & Lingchao Kong & Shenchang Li & Xiongjun Cao & Yang Li & Yi Wang & Ling Lin & Rongrong Guo & Taili Xie & Wei Duan & Zhanwu Dai & Peige Fan & Shaohua Li & Zhenchang, 2025. "A naturally occurring SNP modulates thermotolerance divergence among grapevines," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60209-2
    DOI: 10.1038/s41467-025-60209-2
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