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Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk

Author

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  • Filippos Anagnostakis

    (Columbia University)

  • Sarah Ko

    (Columbia University)

  • Mehrshad Saadatinia

    (Columbia University)

  • Jingyue Wang

    (Columbia University)

  • Christos Davatzikos

    (University of Pennsylvania)

  • Junhao Wen

    (Columbia University
    Columbia University
    New York Genome Center (NYGC)
    Columbia University)

Abstract

Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based biological age gaps (MetBAGs) using 107 plasma non-derivatized metabolites from 274,247 UK Biobank participants. Our age prediction models achieve a mean absolute error of approximately 6 years (0.25

Suggested Citation

  • Filippos Anagnostakis & Sarah Ko & Mehrshad Saadatinia & Jingyue Wang & Christos Davatzikos & Junhao Wen, 2025. "Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59964-z
    DOI: 10.1038/s41467-025-59964-z
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