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Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study

Author

Listed:
  • Richard Dumbill

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust)

  • Simon Knight

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust)

  • James Hunter

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust
    University Hospitals Coventry and Warwickshire)

  • John Fallon

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust)

  • Daniel Voyce

    (OrganOx Ltd
    University of Oxford)

  • Jacob Barrett

    (OrganOx Ltd)

  • Matt Ellen

    (OrganOx Ltd)

  • Elizabeth Conroy

    (University of Oxford)

  • Ian SD Roberts

    (Oxford University Hospitals NHS Foundation Trust)

  • Tim James

    (Oxford University Hospitals NHS Foundation Trust)

  • Gabrielle Allen

    (Oxford University Hospitals NHS Foundation Trust)

  • Jennifer Brook

    (Oxford University Hospitals NHS Foundation Trust)

  • Annemarie Weissenbacher

    (Medical University of Innsbruck)

  • Rutger Ploeg

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust)

  • Constantin Coussios

    (OrganOx Ltd
    University of Oxford)

  • Peter Friend

    (University of Oxford
    Oxford University Hospitals NHS Foundation Trust
    OrganOx Ltd)

Abstract

Kidney transplantation is the preferred treatment for end-stage renal disease and is limited by donor organ availability. Normothermic Machine Perfusion (NMP) might facilitate safe transplantation of marginal organs. NKP1 is a single centre, phase 1, 36-patient, three-stage cohort study investigating the safety and feasibility of up to 24 hours of renal NMP prior to transplantation. 30-day graft survival (primary endpoint) was 100%. Secondary objectives were assessment of the effect of NMP on post-transplant clinical outcomes and ischaemia-reperfusion injury, identification of predictive biomarkers, and characterisation of the performance of the preservation system. Clinical outcomes were comparable to a matched control cohort with 12-month estimated glomerular filtration rate (eGFR) 46.3 vs 49.5 mL/min/1.73m2 (p = 0.44) despite much longer total preservation times (15.7 vs 8.9 hours controls, p

Suggested Citation

  • Richard Dumbill & Simon Knight & James Hunter & John Fallon & Daniel Voyce & Jacob Barrett & Matt Ellen & Elizabeth Conroy & Ian SD Roberts & Tim James & Gabrielle Allen & Jennifer Brook & Annemarie W, 2025. "Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59829-5
    DOI: 10.1038/s41467-025-59829-5
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