ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
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DOI: 10.1038/s41467-025-59444-4
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- Kathryn Tunyasuvunakool & Jonas Adler & Zachary Wu & Tim Green & Michal Zielinski & Augustin Žídek & Alex Bridgland & Andrew Cowie & Clemens Meyer & Agata Laydon & Sameer Velankar & Gerard J. Kleywegt, 2021. "Highly accurate protein structure prediction for the human proteome," Nature, Nature, vol. 596(7873), pages 590-596, August.
- Christina Gladkova & Sarah L. Maslen & J. Mark Skehel & David Komander, 2018. "Mechanism of parkin activation by PINK1," Nature, Nature, vol. 559(7714), pages 410-414, July.
- Inga V. Hochheiser & Michael Pilsl & Gregor Hagelueken & Jonas Moecking & Michael Marleaux & Rebecca Brinkschulte & Eicke Latz & Christoph Engel & Matthias Geyer, 2022. "Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3," Nature, Nature, vol. 604(7904), pages 184-189, April.
- John Jumper & Richard Evans & Alexander Pritzel & Tim Green & Michael Figurnov & Olaf Ronneberger & Kathryn Tunyasuvunakool & Russ Bates & Augustin Žídek & Anna Potapenko & Alex Bridgland & Clemens Me, 2021. "Highly accurate protein structure prediction with AlphaFold," Nature, Nature, vol. 596(7873), pages 583-589, August.
- Benjamin Stieglitz & Rohini R. Rana & Marios G. Koliopoulos & Aylin C. Morris-Davies & Veronique Schaeffer & Evangelos Christodoulou & Steven Howell & Nicholas R. Brown & Ivan Dikic & Katrin Rittinger, 2013. "Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP," Nature, Nature, vol. 503(7476), pages 422-426, November.
- Daniel Horn-Ghetko & David T. Krist & J. Rajan Prabu & Kheewoong Baek & Monique P. C. Mulder & Maren Klügel & Daniel C. Scott & Huib Ovaa & Gary Kleiger & Brenda A. Schulman, 2021. "Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly," Nature, Nature, vol. 590(7847), pages 671-676, February.
- Hiroki Kato & Osamu Takeuchi & Shintaro Sato & Mitsutoshi Yoneyama & Masahiro Yamamoto & Kosuke Matsui & Satoshi Uematsu & Andreas Jung & Taro Kawai & Ken J. Ishii & Osamu Yamaguchi & Kinya Otsu & Toh, 2006. "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses," Nature, Nature, vol. 441(7089), pages 101-105, May.
- Sonia Alcalá & Patricia Sancho & Paola Martinelli & Diego Navarro & Coral Pedrero & Laura Martín-Hijano & Sandra Valle & Julie Earl & Macarena Rodríguez-Serrano & Laura Ruiz-Cañas & Katerin Rojas & Al, 2020. "ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
- Elsje G. Otten & Emma Werner & Ana Crespillo-Casado & Keith B. Boyle & Vimisha Dharamdasani & Claudio Pathe & Balaji Santhanam & Felix Randow, 2021. "Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection," Nature, Nature, vol. 594(7861), pages 111-116, June.
- Kuan-Chuan Pao & Nicola T. Wood & Axel Knebel & Karim Rafie & Mathew Stanley & Peter D. Mabbitt & Ramasubramanian Sundaramoorthy & Kay Hofmann & Daan M. F. Aalten & Satpal Virdee, 2018. "Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity," Nature, Nature, vol. 556(7701), pages 381-385, April.
- Fabien Thery & Lia Martina & Caroline Asselman & Yifeng Zhang & Madeleine Vessely & Heidi Repo & Koen Sedeyn & George D. Moschonas & Clara Bredow & Qi Wen Teo & Jingshu Zhang & Kevin Leandro & Denzel , 2021. "Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity," Nature Communications, Nature, vol. 12(1), pages 1-21, December.
- Bernhard C. Lechtenberg & Akhil Rajput & Ruslan Sanishvili & Małgorzata K. Dobaczewska & Carl F. Ware & Peter D. Mace & Stefan J. Riedl, 2016. "Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation," Nature, Nature, vol. 529(7587), pages 546-550, January.
- Gwen R. Buel & Xiang Chen & Raj Chari & Maura J. O’Neill & Danielle L. Ebelle & Conor Jenkins & Vinidhra Sridharan & Sergey G. Tarasov & Nadya I. Tarasova & Thorkell Andresson & Kylie J. Walters, 2020. "Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
- Aylwyn Scally & Julien Y. Dutheil & LaDeana W. Hillier & Gregory E. Jordan & Ian Goodhead & Javier Herrero & Asger Hobolth & Tuuli Lappalainen & Thomas Mailund & Tomas Marques-Bonet & Shane McCarthy &, 2012. "Insights into hominid evolution from the gorilla genome sequence," Nature, Nature, vol. 483(7388), pages 169-175, March.
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