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Iron-catalyzed sequential hydrosilylation

Author

Listed:
  • Xue Wang

    (Zhejiang University)

  • Jiajin Zhao

    (Zhejiang University)

  • Dongyang Wang

    (Chinese Academy of Sciences)

  • Liang Deng

    (Chinese Academy of Sciences)

  • Zhan Lu

    (Zhejiang University)

Abstract

Highly regio-, diastereo- and enantioselective iron-catalyzed sequential hydrosilylation of o-alk-n-enyl-phenyl silanes with alkynes is reported for various 5-, 6-, and 7-membered benzosilacycles in 60-94% yields with up to 95:5 rr, 95:5 dr, and 99% ee. Chiral fully carbon-substituted silicon-stereogenic benzosilacycles could also be obtained via triple hydrosilylation reactions. The unique electronic effect of ligands is observed while adjusting the regioselectivity and enantioselectivity in hydrosilylation reactions. A possible mechanism has been proposed by variable time normalization analysis (VTNA) and H/D exchange experiment.

Suggested Citation

  • Xue Wang & Jiajin Zhao & Dongyang Wang & Liang Deng & Zhan Lu, 2025. "Iron-catalyzed sequential hydrosilylation," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59364-3
    DOI: 10.1038/s41467-025-59364-3
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