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Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis

Author

Listed:
  • Yiheng Hu

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jinpeng Wang

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    North China University of Science and Technology)

  • Lumei Liu

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xin Yi

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences)

  • Xin Wang

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jianyu Wang

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ya’nan Hao

    (North China University of Science and Technology)

  • Liuyu Qin

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Kunpeng Li

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yishan Feng

    (North China University of Science and Technology)

  • Zhongshuai Zhang

    (Chinese Academy of Forestry)

  • Hanying Wu

    (the Chinese Academy of Sciences)

  • Yuannian Jiao

    (the Chinese Academy of Sciences
    the Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    China National Botanical Garden)

Abstract

Benzylisoquinoline alkaloids (BIAs) are important metabolites synthesized in early-diverging eudicots and magnoliids, yet the genetic basis of BIA biosynthesis in magnoliids remains unclear. Here, we decode the genomes of two magnoliid species, Saruma henryi and Aristolochia manshuriensis, and reconstruct the ancestral magnoliid karyotype and infer the chromosomal rearrangement history following magnoliid diversification. Metabolomic, transcriptomic, and phylogenetic analyses reveal the intermediate chemical components and genetic basis of BIA biosynthesis in A. manshuriensis. Although the core enzymes involved in BIA synthesis appear to be largely conserved between early-diverging eudicots and magnoliids, the biosynthetic pathways in magnoliids seem to exhibit greater flexibility. Significantly, our investigation of the evolutionary history of BIA biosynthetic genes revealed that almost all were duplicated before the emergence of extant angiosperms, with only early-diverging eudicots and magnoliids preferentially retaining these duplicated genes, thereby enabling the biosynthesis of BIAs in these groups.

Suggested Citation

  • Yiheng Hu & Jinpeng Wang & Lumei Liu & Xin Yi & Xin Wang & Jianyu Wang & Ya’nan Hao & Liuyu Qin & Kunpeng Li & Yishan Feng & Zhongshuai Zhang & Hanying Wu & Yuannian Jiao, 2025. "Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59343-8
    DOI: 10.1038/s41467-025-59343-8
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