IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-59242-y.html
   My bibliography  Save this article

Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV

Author

Listed:
  • Haijiang Lin

    (Fudan University
    Taizhou City Center for Disease Control and Prevention)

  • Jiayu He

    (Fudan University
    Fudan University
    Fudan University)

  • Jiyuan Ren

    (Fudan University
    Fudan University
    Fudan University)

  • Xiaoxiao Chen

    (Fudan University
    Taizhou City Center for Disease Control and Prevention)

  • Tingting Wang

    (Taizhou City Center for Disease Control and Prevention)

  • Haijun Zhang

    (Taizhou City Center for Disease Control and Prevention)

  • Shanling Wang

    (Taizhou City Center for Disease Control and Prevention)

  • Miaochen Wang

    (Fudan University
    Fudan University
    Fudan University)

  • Tailin Chen

    (Fudan University
    Fudan University
    Fudan University)

  • Song Duan

    (Dehong Prefecture Center for Disease Control and Prevention)

  • Na He

    (Fudan University
    Fudan University
    Fudan University)

Abstract

Antiretroviral therapy (ART) is shifting the primary driver of mortality for people with HIV (PWH) from opportunistic infections to noncommunicable diseases (NCDs). Protein biomarkers differentiating both AIDS-related and NCDs-related deaths from PWH may help early and precise risk prediction and intervention. We conduct a nested case-control study where 126 HIV deaths, 162 age-sex-matched HIV survivors and 152 HIV-negative controls are analyzed with 92 protein biomarkers of the Olink Organ Damage panel by proximity extension assays (PEA). Using LASSO regression, logistic regression, and ROC analysis, twelve proteins are significantly associated with HIV death, of which six (SIRT5, PPM1B, PSMA1, GALNT10, VEGFC, PTN) are specifically associated with NCDs-related death, two (RCOR1, SERPINA9) are specifically associated with AIDS-related death, and four (CA12, CA14, RARRES1, EDIL3) are associated with both. Three of these proteins are replicable in the external validation sample. The adjusted protein panels consisting of significantly associated proteins selected through both LASSO and logistic regression model well predicted NCDs-related death (AUC = 0.970) and AIDS-related death (AUC = 0.960) in PWH. The selected proteins also displayed a significant correlation with traditional biomarkers of NCDs among PWH (P

Suggested Citation

  • Haijiang Lin & Jiayu He & Jiyuan Ren & Xiaoxiao Chen & Tingting Wang & Haijun Zhang & Shanling Wang & Miaochen Wang & Tailin Chen & Song Duan & Na He, 2025. "Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59242-y
    DOI: 10.1038/s41467-025-59242-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-59242-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-59242-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Victor Riitho & Roisin Connon & Agnes Gwela & Josephine Namusanje & Ruth Nhema & Abraham Siika & Mutsa Bwakura-Dangarembizi & Victor Musiime & James A. Berkley & Alex J. Szubert & Diana M. Gibb & A. S, 2024. "Biomarkers of mortality in adults and adolescents with advanced HIV in sub-Saharan Africa," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-59242-y. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.