IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-58977-y.html
   My bibliography  Save this article

Disease-specific B cell clones are shared between patients with Crohn’s disease

Author

Listed:
  • Prasanti Kotagiri

    (University of Cambridge
    University of Cambridge School of Clinical Medicine
    Monash University
    Stanford University)

  • William M. Rae

    (University of Cambridge
    University of Cambridge School of Clinical Medicine
    Cambridge Biomedical Campus)

  • Laura Bergamaschi

    (University of Cambridge
    University of Cambridge School of Clinical Medicine)

  • Diana Pombal

    (University of Cambridge School of Clinical Medicine)

  • Ji-Yeun Lee

    (Stanford University)

  • Nurulamin M. Noor

    (University of Cambridge School of Clinical Medicine)

  • Raoul S. Sojwal

    (Stanford University)

  • Samuel J. S. Rubin

    (Stanford University)

  • Lukas W. Unger

    (University of Cambridge
    University of Cambridge School of Clinical Medicine
    Medical University of Vienna)

  • Sofie H. Tolmeijer

    (University of Cambridge School of Clinical Medicine)

  • Giulia Manferrari

    (University of Cambridge School of Clinical Medicine)

  • Rachael J. M. Bashford-Rogers

    (University of Cambridge School of Clinical Medicine
    University of Oxford)

  • David B. Bingham

    (Stanford University)

  • Anton Stift

    (Medical University of Vienna)

  • Stephan Rogalla

    (Stanford University)

  • John Gubatan

    (Stanford University)

  • James C. Lee

    (University of Cambridge
    Royal Free Campus)

  • Kenneth G. C. Smith

    (University of Cambridge
    University of Cambridge School of Clinical Medicine)

  • Eoin F. McKinney

    (University of Cambridge
    University of Cambridge School of Clinical Medicine)

  • Scott D. Boyd

    (Stanford University)

  • Paul A. Lyons

    (University of Cambridge
    University of Cambridge School of Clinical Medicine)

Abstract

B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients.

Suggested Citation

  • Prasanti Kotagiri & William M. Rae & Laura Bergamaschi & Diana Pombal & Ji-Yeun Lee & Nurulamin M. Noor & Raoul S. Sojwal & Samuel J. S. Rubin & Lukas W. Unger & Sofie H. Tolmeijer & Giulia Manferrari, 2025. "Disease-specific B cell clones are shared between patients with Crohn’s disease," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58977-y
    DOI: 10.1038/s41467-025-58977-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-58977-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-58977-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kathrin Moor & Médéric Diard & Mikael E. Sellin & Boas Felmy & Sandra Y. Wotzka & Albulena Toska & Erik Bakkeren & Markus Arnoldini & Florence Bansept & Alma Dal Co & Tom Völler & Andrea Minola & Blan, 2017. "High-avidity IgA protects the intestine by enchaining growing bacteria," Nature, Nature, vol. 544(7651), pages 498-502, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cyril Planchais & Luis M. Molinos-Albert & Pierre Rosenbaum & Thierry Hieu & Alexia Kanyavuz & Dominique Clermont & Thierry Prazuck & Laurent Lefrou & Jordan D. Dimitrov & Sophie Hüe & Laurent Hocquel, 2023. "HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Noemi Santamaria de Souza & Yassine Cherrak & Thea Bill Andersen & Michel Vetsch & Manja Barthel & Sanne Kroon & Erik Bakkeren & Christopher Schubert & Philipp Christen & Patrick Kiefer & Julia A. Vor, 2025. "Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    3. Qianqiao Liu & Beth M. Stadtmueller, 2023. "SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58977-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.