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Recent perspectives in clinical development of malaria vaccines

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Listed:
  • Jack Feehan

    (Bundoora)

  • Magdalena Plebanski

    (Bundoora)

  • Vasso Apostolopoulos

    (Bundoora)

Abstract

Malaria vaccine research has progressed significantly, with RTS,S/AS01 and R21/Matrix-M receiving WHO endorsement in 2021 / 2023. These vaccines show promise, but challenges like vaccine adherence, strain variation, and resistance persist, highlighting the need for more effective, broad-reaching interventions.

Suggested Citation

  • Jack Feehan & Magdalena Plebanski & Vasso Apostolopoulos, 2025. "Recent perspectives in clinical development of malaria vaccines," Nature Communications, Nature, vol. 16(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58963-4
    DOI: 10.1038/s41467-025-58963-4
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    References listed on IDEAS

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    1. Zita Sulyok & Rolf Fendel & Bianca Eder & Freia-Raphaella Lorenz & Natasha KC & Matthias Karnahl & Albert Lalremruata & The T. Nguyen & Jana Held & Folashade Almeine Cyntiche Adjadi & Torsten Klockenb, 2021. "Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Agnes Mwakingwe-Omari & Sara A. Healy & Jacquelyn Lane & David M. Cook & Sahand Kalhori & Charles Wyatt & Aarti Kolluri & Omely Marte-Salcedo & Alemush Imeru & Martha Nason & Lei K. Ding & Hope Decede, 2021. "Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity," Nature, Nature, vol. 595(7866), pages 289-294, July.
    3. Myriam Arévalo-Herrera & Xiomara Gaitán & Michelle Larmat-Delgado & María Alejandra Caicedo & Sonia M. Herrera & Juliana Henao-Giraldo & Angélica Castellanos & Jean-Christophe Devaud & André Pannatier, 2022. "Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
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