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Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Author

Listed:
  • Xinruo Zhang

    (University of North Carolina at Chapel Hill)

  • Jennifer A. Brody

    (University of Washington)

  • Mariaelisa Graff

    (University of North Carolina at Chapel Hill)

  • Heather M. Highland

    (University of North Carolina at Chapel Hill)

  • Nathalie Chami

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Hanfei Xu

    (Boston University)

  • Zhe Wang

    (Icahn School of Medicine at Mount Sinai)

  • Kendra R. Ferrier

    (University of Colorado School of Medicine, Anschutz Medical Campus)

  • Geetha Chittoor

    (Geisinger)

  • Navya Shilpa Josyula

    (Geisinger)

  • Mariah Meyer

    (University of Colorado School of Medicine, Anschutz Medical Campus)

  • Shreyash Gupta

    (Geisinger)

  • Xihao Li

    (Harvard T.H. Chan School of Public Health
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Zilin Li

    (Indiana University School of Medicine
    Northeast Normal University)

  • Matthew A. Allison

    (The University of California San Diego)

  • Diane M. Becker

    (Johns Hopkins University School of Medicine)

  • Lawrence F. Bielak

    (University of Michigan)

  • Joshua C. Bis

    (University of Washington)

  • Meher Preethi Boorgula

    (University of Colorado School of Medicine)

  • Donald W. Bowden

    (Wake Forest School of Medicine)

  • Jai G. Broome

    (University of Washington
    University of Washington)

  • Erin J. Buth

    (University of Washington)

  • Christopher S. Carlson

    (Fred Hutchinson Cancer Center)

  • Kyong-Mi Chang

    (The Corporal Michael J. Crescenz VA Medical Center
    University of Pennsylvania Perelman School of Medicine)

  • Sameer Chavan

    (University of Colorado School of Medicine)

  • Yen-Feng Chiu

    (National Health Research Institutes)

  • Lee-Ming Chuang

    (National Taiwan University Hospital)

  • Matthew P. Conomos

    (University of Washington)

  • Dawn L. DeMeo

    (Harvard Medical School)

  • Mengmeng Du

    (Memorial Sloan Kettering Cancer Center)

  • Ravindranath Duggirala

    (Texas A&M University-San Antonio
    Texas A&M University-San Antonio)

  • Celeste Eng

    (University of California, San Francisco)

  • Alison E. Fohner

    (University of Washington)

  • Barry I. Freedman

    (Wake Forest School of Medicine)

  • Melanie E. Garrett

    (Duke University Medical Center)

  • Xiuqing Guo

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Chris Haiman

    (University of Southern California)

  • Benjamin D. Heavner

    (University of Washington)

  • Bertha Hidalgo

    (University of Alabama at Birmingham School of Public Health)

  • James E. Hixson

    (UTHealth Houston)

  • Yuk-Lam Ho

    (Veterans Affairs Boston Healthcare System)

  • Brian D. Hobbs

    (Harvard Medical School
    Harvard Medical School)

  • Donglei Hu

    (University of California, San Francisco)

  • Qin Hui

    (Emory University Rollins School of Public Health
    Atlanta VA Health Care System)

  • Chii-Min Hwu

    (Taipei Veterans General Hospital)

  • Rebecca D. Jackson

    (Ohio State University)

  • Deepti Jain

    (University of Washington)

  • Rita R. Kalyani

    (Johns Hopkins University School of Medicine)

  • Sharon L. R. Kardia

    (University of Michigan)

  • Tanika N. Kelly

    (Tulane University)

  • Ethan M. Lange

    (University of Colorado School of Medicine, Anschutz Medical Campus)

  • Michael LeNoir

    (Bay Area Pediatrics)

  • Changwei Li

    (Tulane University)

  • Loic Marchand

    (University of Hawaii Cancer Center)

  • Merry-Lynn N. McDonald

    (University of Alabama at Birmingham)

  • Caitlin P. McHugh

    (University of Washington)

  • Alanna C. Morrison

    (The University of Texas Health Science Center at Houston)

  • Take Naseri

    (Naseri & Associates Public Health Consultancy Firm and Family Health Clinic
    Brown University)

  • Jeffrey O’Connell

    (University of Maryland)

  • Christopher J. O’Donnell

    (Veterans Affairs Boston Healthcare System
    Harvard Medical School)

  • Nicholette D. Palmer

    (Wake Forest School of Medicine)

  • James S. Pankow

    (University of Minnesota)

  • James A. Perry

    (University of Maryland)

  • Ulrike Peters

    (Fred Hutchinson Cancer Center)

  • Michael H. Preuss

    (Icahn School of Medicine at Mount Sinai)

  • D. C. Rao

    (Washington University in St. Louis)

  • Elizabeth A. Regan

    (National Jewish Health)

  • Sefuiva M. Reupena

    (Lutia i Puava ae Mapu i Fagalele)

  • Dan M. Roden

    (Vanderbilt University Medical Center)

  • Jose Rodriguez-Santana

    (Centro de Neumologia Pediatrica)

  • Colleen M. Sitlani

    (University of Washington)

  • Jennifer A. Smith

    (University of Michigan
    University of Michigan)

  • Hemant K. Tiwari

    (University of Alabama at Birmingham School of Public Health)

  • Ramachandran S. Vasan

    (Boston University)

  • Zeyuan Wang

    (Emory University Rollins School of Public Health)

  • Daniel E. Weeks

    (University of Pittsburgh
    University of Pittsburgh)

  • Jennifer Wessel

    (Indiana University
    Indiana University
    Indiana University)

  • Kerri L. Wiggins

    (University of Washington)

  • Lynne R. Wilkens

    (University of Hawaii Cancer Center)

  • Peter W. F. Wilson

    (Atlanta VA Health Care System
    Emory University School of Medicine)

  • Lisa R. Yanek

    (Johns Hopkins University School of Medicine)

  • Zachary T. Yoneda

    (Vanderbilt University Medical Center)

  • Wei Zhao

    (University of Michigan
    University of Michigan)

  • Sebastian Zöllner

    (University of Michigan)

  • Donna K. Arnett

    (University of South Carolina)

  • Allison E. Ashley-Koch

    (Duke University Medical Center)

  • Kathleen C. Barnes

    (University of Colorado School of Medicine)

  • John Blangero

    (University of Texas Rio Grande Valley)

  • Eric Boerwinkle

    (The University of Texas Health Science Center at Houston)

  • Esteban G. Burchard

    (University of California, San Francisco)

  • April P. Carson

    (University of Mississippi Medical Center)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Yii-Der Ida Chen

    (Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Joanne E. Curran

    (University of Texas Rio Grande Valley)

  • Myriam Fornage

    (The University of Texas Health Science Center at Houston
    University of Texas Health Science Center at Houston)

  • Victor R. Gordeuk

    (University of Illinois at Chicago)

  • Jiang He

    (Tulane University)

  • Susan R. Heckbert

    (University of Washington
    University of Washington)

  • Lifang Hou

    (Northwestern University)

  • Marguerite R. Irvin

    (University of Alabama at Birmingham School of Public Health)

  • Charles Kooperberg

    (Fred Hutchinson Cancer Center)

  • Ryan L. Minster

    (University of Pittsburgh)

  • Braxton D. Mitchell

    (University of Maryland)

  • Mehdi Nouraie

    (University of Pittsburgh)

  • Bruce M. Psaty

    (University of Washington
    University of Washington
    University of Washington)

  • Laura M. Raffield

    (University of North Carolina at Chapel Hill)

  • Alexander P. Reiner

    (University of Washington)

  • Stephen S. Rich

    (University of Virginia)

  • Jerome I. Rotter

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • M. Benjamin Shoemaker

    (Vanderbilt University Medical Center)

  • Nicholas L. Smith

    (University of Washington
    Kaiser Permanente Washington
    Department of Veterans Affairs)

  • Kent D. Taylor

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Marilyn J. Telen

    (Duke University School of Medical)

  • Scott T. Weiss

    (Harvard Medical School)

  • Yingze Zhang

    (University of Pittsburgh)

  • Nancy Heard-Costa

    (Boston University Chobanian & Avedisian School of Medicine)

  • Yan V. Sun

    (Emory University Rollins School of Public Health
    Atlanta VA Health Care System)

  • Xihong Lin

    (Harvard T.H. Chan School of Public Health
    Harvard University)

  • L. Adrienne Cupples

    (Boston University)

  • Leslie A. Lange

    (University of Colorado School of Medicine, Anschutz Medical Campus)

  • Ching-Ti Liu

    (Boston University)

  • Ruth J. F. Loos

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    University of Copenhagen)

  • Kari E. North

    (University of North Carolina at Chapel Hill)

  • Anne E. Justice

    (Geisinger)

Abstract

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P

Suggested Citation

  • Xinruo Zhang & Jennifer A. Brody & Mariaelisa Graff & Heather M. Highland & Nathalie Chami & Hanfei Xu & Zhe Wang & Kendra R. Ferrier & Geetha Chittoor & Navya Shilpa Josyula & Mariah Meyer & Shreyash, 2025. "Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58420-2
    DOI: 10.1038/s41467-025-58420-2
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