IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-58147-0.html
   My bibliography  Save this article

An epidermal serine sensing system for skin healthcare

Author

Listed:
  • Ying Yuan

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Beijing Forestry University)

  • Bowen Zhong

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiaokun Qin

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hao Xu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhexin Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Linlin Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiaofeng Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wenxuan Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zheng Lou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yongming Fan

    (Beijing Forestry University)

  • Lili Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Portable biosensors mainly focus on detecting biomarkers in biofluids but neglect the abundant skin biomarkers on the stratum corneum, which are associated with the functionality and integrity of the skin barrier. Here, we propose a sensing patch designed for direct sampling and in situ quantification of epidermal serine, an important biomarker for skin healthcare. The patch consists of a porous hydrogel for serine diffusion and ion conduction, and a molecular imprinted polymer-based electrochemical serine sensor. By integrating with a customized handheld serine tester, the serine sensing system enables in situ measurement of epidermal serine levels. We demonstrate the application of this serine sensing system in assessing the moisturizing effect of a skincare product and tracking the recovery progress of skin barrier function in a patient with atopic dermatitis. Our work opens up a potential application scenario for portable biosensors in personalized skin healthcare.

Suggested Citation

  • Ying Yuan & Bowen Zhong & Xiaokun Qin & Hao Xu & Zhexin Li & Linlin Li & Xiaofeng Wang & Wenxuan Zhang & Zheng Lou & Yongming Fan & Lili Wang, 2025. "An epidermal serine sensing system for skin healthcare," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58147-0
    DOI: 10.1038/s41467-025-58147-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-58147-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-58147-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bowen Zhong & Xiaokun Qin & Hao Xu & Lingchen Liu & Linlin Li & Zhexin Li & Limin Cao & Zheng Lou & Joshua A. Jackman & Nam-Joon Cho & Lili Wang, 2024. "Interindividual- and blood-correlated sweat phenylalanine multimodal analytical biochips for tracking exercise metabolism," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58147-0. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.