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High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China

Author

Listed:
  • Xin Lu

    (Chinese Center for Disease Control and Prevention)

  • Ming Luo

    (Yulin Center for Disease Control and Prevention)

  • Mengyu Wang

    (Chinese Center for Disease Control and Prevention
    Shandong University)

  • Zhemin Zhou

    (Chinese Center for Disease Control and Prevention
    Soochow University)

  • Jialiang Xu

    (Beijing Technology and Business University)

  • Zhenpeng Li

    (Chinese Center for Disease Control and Prevention)

  • Yao Peng

    (Chinese Center for Disease Control and Prevention)

  • Yuan Zhang

    (Chinese Center for Disease Control and Prevention)

  • Fangyu Ding

    (Chinese Academy of Sciences)

  • Dong Jiang

    (Chinese Academy of Sciences)

  • Changyu Zhou

    (Yulin Center for Disease Control and Prevention)

  • Liya Yang

    (Chinese Center for Disease Control and Prevention
    Beijing Technology and Business University)

  • Wenxuan Zhao

    (Chinese Center for Disease Control and Prevention)

  • Tian Ma

    (Chinese Academy of Sciences)

  • Bo Pang

    (Chinese Center for Disease Control and Prevention)

  • Meiying Yan

    (Chinese Center for Disease Control and Prevention)

  • Yongning Wu

    (China National Center for Food Safety Risk Assessment)

  • Yannong Wu

    (Yulin Center for Disease Control and Prevention)

  • Biao Kan

    (Chinese Center for Disease Control and Prevention
    Shandong University)

Abstract

Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers. The isolates from food workers also exhibited greater serovar diversity and likely higher levels of antimicrobial resistance than those from non-food workers. Factors such as meteorological, social, and hygiene factors potentially influenced the carriage rate. Genomic analysis revealed a consistent increase in antimicrobial resistance genes among Salmonella isolates over the study period, with the majority of these antimicrobial resistance genes located on plasmids. Additionally, we identified numerous closely related bacterial clusters, which might reflect clusters of hidden local foodborne infections. This study underscores the elevated risk posed by food workers in the persistence and dissemination of Salmonella as vectors/fomites. Enhanced monitoring and targeted interventions in this group may reduce the dissemination of pathogens and antimicrobial resistance genes.

Suggested Citation

  • Xin Lu & Ming Luo & Mengyu Wang & Zhemin Zhou & Jialiang Xu & Zhenpeng Li & Yao Peng & Yuan Zhang & Fangyu Ding & Dong Jiang & Changyu Zhou & Liya Yang & Wenxuan Zhao & Tian Ma & Bo Pang & Meiying Yan, 2024. "High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54405-9
    DOI: 10.1038/s41467-024-54405-9
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    References listed on IDEAS

    as
    1. Shaoting Li & Yingshu He & David Ames Mann & Xiangyu Deng, 2021. "Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Iman Yassine & Sophie Lefèvre & Elisabeth E. Hansen & Corinne Ruckly & Isabelle Carle & Monique Lejay-Collin & Laëtitia Fabre & Rayane Rafei & Dominique Clermont & Maria Pardos Gandara & Fouad Dabbous, 2022. "Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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