IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-54078-4.html
   My bibliography  Save this article

Effectiveness of treat-to-target cholesterol-lowering interventions on cardiovascular disease and all-cause mortality risk in the community-dwelling population: a target trial emulation

Author

Listed:
  • Zhao Yang

    (Lung and Blood Vessel Diseases)

  • Qiujv Deng

    (Lung and Blood Vessel Diseases)

  • Yongchen Hao

    (Lung and Blood Vessel Diseases)

  • Na Yang

    (Lung and Blood Vessel Diseases)

  • Lizhen Han

    (Lung and Blood Vessel Diseases)

  • Pingping Jia

    (Lung and Blood Vessel Diseases)

  • Pan Zhou

    (Lung and Blood Vessel Diseases)

  • Yiming Hao

    (Lung and Blood Vessel Diseases)

  • Ziyu Wang

    (Lung and Blood Vessel Diseases)

  • Wenlang Zhao

    (Lung and Blood Vessel Diseases)

  • Yue Qi

    (Lung and Blood Vessel Diseases)

  • Jing Liu

    (Lung and Blood Vessel Diseases)

Abstract

Little is known about the long-term effectiveness of risk-based treat-to-target cholesterol-lowering interventions on cardiovascular risk. Here, we show the emulated effectiveness of guideline-recommended low-density and non-high-density lipoprotein cholesterol-lowering interventions using the absolute risk reduction (ARR) and the restricted mean event-free time-based number needed to treat (NNT). With 5,375 participants, the 29-year risks for cardiovascular disease (CVD), all-cause mortality, and atherosclerotic CVD were 18.6%, 25.6%, and 17.7%, respectively. Long-term treat-to-target interventions showed significant reductions in CVD (ARR −2.3%, 95%CI −3.4% to −0.8%; NNT 115), all-cause mortality (−3.0%, −4.3% to −1.8%; 95), and atherosclerotic CVD (−2.6%, −3.5% to −1.2%; 104). Such effects appear more pronounced in women, smokers, and those with body mass index

Suggested Citation

  • Zhao Yang & Qiujv Deng & Yongchen Hao & Na Yang & Lizhen Han & Pingping Jia & Pan Zhou & Yiming Hao & Ziyu Wang & Wenlang Zhao & Yue Qi & Jing Liu, 2024. "Effectiveness of treat-to-target cholesterol-lowering interventions on cardiovascular disease and all-cause mortality risk in the community-dwelling population: a target trial emulation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54078-4
    DOI: 10.1038/s41467-024-54078-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-54078-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-54078-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54078-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.