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Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study

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Listed:
  • Fiona A. Chapman

    (University of Edinburgh
    Royal Infirmary of Edinburgh)

  • Vanessa Melville

    (University of Edinburgh)

  • Emily Godden

    (University of Edinburgh)

  • Beth Morrison

    (University of Edinburgh)

  • Lorraine Bruce

    (University of Edinburgh)

  • Janet J. Maguire

    (University of Cambridge)

  • Anthony P. Davenport

    (University of Cambridge)

  • David E. Newby

    (University of Edinburgh)

  • Neeraj Dhaun

    (University of Edinburgh
    Royal Infirmary of Edinburgh)

Abstract

Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed. Here, we investigated the systemic and renal effects of apelin in CKD. In a randomized, double-blind, placebo-controlled, crossover study, 24 subjects (12 patients with CKD and 12 matched healthy subjects) received pyroglutamated apelin-13 ([Pyr1]apelin-13, 1 nmol/min and 30 nmol/min) or matched placebo on two separate visits. Systemic and renal hemodynamics were monitored throughout. The co-primary endpoints were change in systemic vascular resistance index and renal blood flow. Secondary endpoints were change in blood pressure, cardiac output, pulse wave velocity, glomerular filtration rate, natriuresis, free water clearance and urinary protein excretion. In both health and CKD, 30 nmol/min [Pyr1]apelin-13 reduced mean arterial pressure by ~4%, systemic vascular resistance by ~12%, and increased cardiac index by ~10%, compared to placebo (p

Suggested Citation

  • Fiona A. Chapman & Vanessa Melville & Emily Godden & Beth Morrison & Lorraine Bruce & Janet J. Maguire & Anthony P. Davenport & David E. Newby & Neeraj Dhaun, 2024. "Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52447-7
    DOI: 10.1038/s41467-024-52447-7
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