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Detection of distant relatedness in biobanks to identify undiagnosed cases of Mendelian disease as applied to Long QT syndrome

Author

Listed:
  • Megan C. Lancaster

    (Vanderbilt University Medical Center)

  • Hung-Hsin Chen

    (Vanderbilt University Medical Center
    Academia Sinica)

  • M. Benjamin Shoemaker

    (Vanderbilt University Medical Center)

  • Matthew R. Fleming

    (Vanderbilt University Medical Center)

  • Teresa L. Strickland

    (Vanderbilt University Medical Center)

  • James T. Baker

    (Vanderbilt University Medical Center)

  • Grahame F. Evans

    (Vanderbilt University Medical Center)

  • Hannah G. Polikowsky

    (Vanderbilt University Medical Center)

  • David C. Samuels

    (Vanderbilt University)

  • Chad D. Huff

    (University of Texas MD Anderson Cancer Center)

  • Dan M. Roden

    (Vanderbilt University Medical Center
    Vanderbilt University Medical Center)

  • Jennifer E. Below

    (Vanderbilt University Medical Center)

Abstract

Rare genetic diseases are typically studied in referral populations, resulting in underdiagnosis and biased assessment of penetrance and phenotype. To address this, we develop a generalizable method of genotype inference based on distant relatedness and deploy this to identify undiagnosed Type 5 Long QT Syndrome (LQT5) rare variant carriers in a non-referral population. We identify 9 LQT5 families referred to a single specialty clinic, each carrying p.Asp76Asn, the most common LQT5 variant. We uncover recent common ancestry and a single shared haplotype among probands. Application to a non-referral population of 69,819 BioVU biobank subjects identifies 22 additional subjects sharing this haplotype, which we confirm to carry p.Asp76Asn. Referral and non-referral carriers have prolonged QT interval corrected for heart rate (QTc) compared to controls, and, among carriers, the QTc polygenic score is independently associated with QTc prolongation. Thus, our innovative analysis of shared chromosomal segments identifies undiagnosed cases of genetic disease and refines the understanding of LQT5 penetrance and phenotype.

Suggested Citation

  • Megan C. Lancaster & Hung-Hsin Chen & M. Benjamin Shoemaker & Matthew R. Fleming & Teresa L. Strickland & James T. Baker & Grahame F. Evans & Hannah G. Polikowsky & David C. Samuels & Chad D. Huff & D, 2024. "Detection of distant relatedness in biobanks to identify undiagnosed cases of Mendelian disease as applied to Long QT syndrome," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51977-4
    DOI: 10.1038/s41467-024-51977-4
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    References listed on IDEAS

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