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Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols

Author

Listed:
  • Jia Xu

    (Nanjing University)

  • Yilin Liu

    (Nanjing University)

  • Qing Wang

    (Nanjing University)

  • Xiangzhang Tao

    (Nanjing University)

  • Shengyang Ni

    (Nanjing University)

  • Weigang Zhang

    (Nanjing University)

  • Lei Yu

    (Nanjing University)

  • Yi Pan

    (Nanjing University)

  • Yi Wang

    (Nanjing University)

Abstract

Alkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions. A range of primary, secondary, and tertiary alkylamines are obtained. This practical procedure can be scaled up through electrochemical continuous flow technique.

Suggested Citation

  • Jia Xu & Yilin Liu & Qing Wang & Xiangzhang Tao & Shengyang Ni & Weigang Zhang & Lei Yu & Yi Pan & Yi Wang, 2024. "Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50596-3
    DOI: 10.1038/s41467-024-50596-3
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