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Liquid-liquid reactions performed by cellular reactors

Author

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  • Jinzhe Cao

    (Dalian University of Technology)

  • Shengyang Tao

    (Dalian University of Technology
    Dalian University of Technology
    Dalian University of Technology
    Dalian University of Technology)

Abstract

Liquid-liquid reactions play a significant role in organic synthesis. However, control of the phase interface between incompatible two-phase liquids remains challenging. Moreover, separating liquid acid, base and oxidants from the reactor takes a long time and high cost. To address these issues, we draw inspiration from the structure and function of cells in living organisms and develop a biomimetic 3D-printed cellular reactor. The cellular reactor houses an aqueous phase containing the catalyst or oxidant while immersed in the organic phase reactant. This setup controls the distribution of the phase interface within the organic phase and increases the interface area by 2.3 times. Notably, the cellular reactor and the aqueous phase are removed from the organic phase upon completing the reaction, eliminating additional separation steps and preventing direct contact between the reactor and acidic, alkaline, or oxidizing substances. Furthermore, the cellular reactor offers the advantages of digital design feasibility and cost-effective manufacturing.

Suggested Citation

  • Jinzhe Cao & Shengyang Tao, 2024. "Liquid-liquid reactions performed by cellular reactors," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49953-z
    DOI: 10.1038/s41467-024-49953-z
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    1. Lulu Guo & Jie Cheng & Shuo Lian & Qun Liu & Yan Lu & Yuan Zheng & Kongkai Zhu & Minghui Zhang & Yalei Kong & Chao Zhang & Naikang Rong & Yuming Zhuang & Guoxing Fang & Jingjing Jiang & Tianyao Zhang , 2023. "Structural basis of amine odorant perception by a mammal olfactory receptor," Nature, Nature, vol. 618(7963), pages 193-200, June.
    2. Jun Jie Tan & Jacques P. Guyette & Kenji Miki & Ling Xiao & Gurbani Kaur & Tong Wu & Liye Zhu & Katrina J. Hansen & King-Hwa Ling & David J. Milan & Harald C. Ott, 2021. "Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
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