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LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes

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  • Pengfei Lv

    (China Agricultural University)

  • Xingzhuo Yang

    (China Agricultural University)

  • Juan Du

    (China Agricultural University)

Abstract

To understand aging impact on the circadian rhythm, we screened for factors influencing circadian changes during aging. Our findings reveal that LKRSDH mutation significantly reduces rhythmicity in aged flies. RNA-seq identifies a significant increase in insulin-like peptides (dilps) in LKRSDH mutants due to the combined effects of H3R17me2 and H3K27me3 on transcription. Genetic evidence suggests that LKRSDH regulates age-related circadian rhythm changes through art4 and dilps. ChIP-seq analyzes whole genome changes in H3R17me2 and H3K27me3 histone modifications in young and old flies with LKRSDH mutation and controls. The results reveal a correlation between H3R17me2 and H3K27me3, underscoring the role of LKRSDH in regulating gene expression and modification levels during aging. Overall, our study demonstrates that LKRSDH-dependent histone modifications at dilps sites contribute to age-related circadian rhythm changes. This data offers insights and a foundational reference for aging research by unveiling the relationship between LKRSDH and H3R17me2/H3K27me3 histone modifications in aging.

Suggested Citation

  • Pengfei Lv & Xingzhuo Yang & Juan Du, 2024. "LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47740-4
    DOI: 10.1038/s41467-024-47740-4
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    1. Janine L. Kwapis & Yasaman Alaghband & Enikö A. Kramár & Alberto J. López & Annie Vogel Ciernia & André O. White & Guanhua Shu & Diane Rhee & Christina M. Michael & Emilie Montellier & Yu Liu & Christ, 2018. "Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Sergey Karakashev & Hengrui Zhu & Shuai Wu & Yuhki Yokoyama & Benjamin G. Bitler & Pyoung-Hwa Park & Jeong-Heon Lee & Andrew V. Kossenkov & Krutika Satish Gaonkar & Huihuang Yan & Ronny Drapkin & Jose, 2018. "CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    3. Jean-Pierre Etchegaray & Choogon Lee & Paul A. Wade & Steven M. Reppert, 2003. "Rhythmic histone acetylation underlies transcription in the mammalian circadian clock," Nature, Nature, vol. 421(6919), pages 177-182, January.
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