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Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study

Author

Listed:
  • Hilde Marie Engjom

    (University of Oxford
    Norwegian Institute of Public Health)

  • Rema Ramakrishnan

    (University of Oxford)

  • Nicola Vousden

    (University of Oxford)

  • Kathryn Bunch

    (University of Oxford)

  • Edward Morris

    (Colney Lane)

  • Nigel Simpson

    (University of Leeds)

  • Chris Gale

    (Imperial College)

  • Pat O’Brien

    (Colney Lane
    University College London)

  • Maria Quigley

    (University of Oxford)

  • Peter Brocklehurst

    (University of Birmingham)

  • Jennifer J. Kurinczuk

    (University of Oxford)

  • Marian Knight

    (University of Oxford)

Abstract

There are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.

Suggested Citation

  • Hilde Marie Engjom & Rema Ramakrishnan & Nicola Vousden & Kathryn Bunch & Edward Morris & Nigel Simpson & Chris Gale & Pat O’Brien & Maria Quigley & Peter Brocklehurst & Jennifer J. Kurinczuk & Marian, 2024. "Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47181-z
    DOI: 10.1038/s41467-024-47181-z
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