Author
Listed:
- Renyu Zheng
(University of Washington
Pacific Northwest National Laboratory)
- Mingfei Zhao
(University of Chicago)
- Jingshan S. Du
(Pacific Northwest National Laboratory)
- Tarunya Rao Sudarshan
(Georgia Institute of Technology)
- Yicheng Zhou
(Pacific Northwest National Laboratory)
- Anant K. Paravastu
(Georgia Institute of Technology
Georgia Institute of Technology)
- James J. Yoreo
(Pacific Northwest National Laboratory
University of Washington)
- Andrew L. Ferguson
(University of Chicago)
- Chun-Long Chen
(University of Washington
Pacific Northwest National Laboratory)
Abstract
A long-standing challenge in bioinspired materials is to design and synthesize synthetic materials that mimic the sophisticated structures and functions of natural biomaterials, such as helical protein assemblies that are important in biological systems. Herein, we report the formation of a series of nanohelices from a type of well-developed protein-mimetics called peptoids. We demonstrate that nanohelix structures and supramolecular chirality can be well-controlled through the side-chain chemistry. Specifically, the ionic effects on peptoids from varying the polar side-chain groups result in the formation of either single helical fiber or hierarchically stacked helical bundles. We also demonstrate that the supramolecular chirality of assembled peptoid helices can be controlled by modifying assembling peptoids with a single chiral amino acid side chain. Computational simulations and theoretical modeling predict that minimizing exposure of hydrophobic domains within a twisted helical form presents the most thermodynamically favorable packing of these amphiphilic peptoids and suggests a key role for both polar and hydrophobic domains on nanohelix formation. Our findings establish a platform to design and synthesize chiral functional materials using sequence-defined synthetic polymers.
Suggested Citation
Renyu Zheng & Mingfei Zhao & Jingshan S. Du & Tarunya Rao Sudarshan & Yicheng Zhou & Anant K. Paravastu & James J. Yoreo & Andrew L. Ferguson & Chun-Long Chen, 2024.
"Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality,"
Nature Communications, Nature, vol. 15(1), pages 1-9, December.
Handle:
RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46839-y
DOI: 10.1038/s41467-024-46839-y
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