IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45261-8.html
   My bibliography  Save this article

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Author

Listed:
  • Darja Andreev

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Katerina Kachler

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Mengdan Liu

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Zhejiang University – School of Medicine)

  • Zhu Chen

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Anhui Medical University Affiliated Provincial Hospital)

  • Brenda Krishnacoumar

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    University Hospital Essen, University of Duisburg-Essen)

  • Mark Ringer

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Silke Frey

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Gerhard Krönke

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Charité University Medicine)

  • David Voehringer

    (FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen)

  • Georg Schett

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Aline Bozec

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

Abstract

Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow. The absence of eosinophils in ΔdblGATA mice results in lower bone mass under steady-state conditions and amplified bone loss upon sex hormone deprivation and inflammatory arthritis. Conversely, increased numbers of eosinophils in IL-5 transgenic mice enhance bone mass under steady-state conditions and protect from hormone- and inflammation- mediated bone loss. Eosinophils strongly inhibit the differentiation and demineralization activity of osteoclasts and lead to profound changes in the transcriptional profile of osteoclasts. This osteoclast-suppressive effect of eosinophils is based on the release of eosinophil peroxidase causing impaired reactive oxygen species and mitogen-activated protein kinase induction in osteoclast precursors. In humans, the number and the activity of eosinophils correlates with bone mass in healthy participants and rheumatoid arthritis patients. Taken together, experimental and human data indicate a regulatory function of eosinophils on bone.

Suggested Citation

  • Darja Andreev & Katerina Kachler & Mengdan Liu & Zhu Chen & Brenda Krishnacoumar & Mark Ringer & Silke Frey & Gerhard Krönke & David Voehringer & Georg Schett & Aline Bozec, 2024. "Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45261-8
    DOI: 10.1038/s41467-024-45261-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45261-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45261-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stephan Culemann & Anika Grüneboom & José Ángel Nicolás-Ávila & Daniela Weidner & Katrin Franziska Lämmle & Tobias Rothe & Juan A. Quintana & Philipp Kirchner & Branislav Krljanac & Martin Eberhardt &, 2019. "Locally renewing resident synovial macrophages provide a protective barrier for the joint," Nature, Nature, vol. 572(7771), pages 670-675, August.
    2. Christian E. Jacome-Galarza & Gulce I. Percin & James T. Muller & Elvira Mass & Tomi Lazarov & Jiri Eitler & Martina Rauner & Vijay K. Yadav & Lucile Crozet & Mathieu Bohm & Pierre-Louis Loyher & Gera, 2019. "Developmental origin, functional maintenance and genetic rescue of osteoclasts," Nature, Nature, vol. 568(7753), pages 541-545, April.
    3. Zhu Chen & Darja Andreev & Katharina Oeser & Branislav Krljanac & Axel Hueber & Arnd Kleyer & David Voehringer & Georg Schett & Aline Bozec, 2016. "Th2 and eosinophil responses suppress inflammatory arthritis," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alessandra Nerviani & Marie-Astrid Boutet & Giulia Maria Ghirardi & Katriona Goldmann & Elisabetta Sciacca & Felice Rivellese & Elena Pontarini & Edoardo Prediletto & Federico Abatecola & Mattia Calis, 2024. "Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yongkuk Park & Tadatoshi Sato & Jungwoo Lee, 2023. "Functional and analytical recapitulation of osteoclast biology on demineralized bone paper," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yang Zhao & Jingyuan Ning & Hongqi Teng & Yalan Deng & Marisela Sheldon & Lei Shi & Consuelo Martinez & Jie Zhang & Annie Tian & Yutong Sun & Shinichi Nakagawa & Fan Yao & Hai Wang & Li Ma, 2024. "Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Sang Hun Lee & Byunghyun Kang & Olena Kamenyeva & Tiago Rodrigues Ferreira & Kyoungin Cho & Jaspal S. Khillan & Juraj Kabat & Brian L. Kelsall & David L. Sacks, 2023. "Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Jarred M. Whitlock & Evgenia Leikina & Kamran Melikov & Luis Fernandez Castro & Sandy Mattijssen & Richard J. Maraia & Michael T. Collins & Leonid V. Chernomordik, 2023. "Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45261-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.