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Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle

Author

Listed:
  • Sydney E. Sherman

    (Harvard-MIT Program in Health Science and Technology, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Alexa S. Zammit

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Won-Seok Heo

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Matthew S. Rosen

    (Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
    Harvard Medical School
    Harvard University)

  • Michael J. Cima

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

Abstract

Magnetic resonance imaging is a widespread clinical tool for the detection of soft tissue morphology and pathology. However, the clinical deployment of magnetic resonance imaging scanners is ultimately limited by size, cost, and space constraints. Here, we discuss the design and performance of a low-field single-sided magnetic resonance sensor intended for point-of-care evaluation of skeletal muscle in vivo. The 11 kg sensor has a penetration depth of >8 mm, which allows for an accurate analysis of muscle tissue and can avoid signal from more proximal layers, including subcutaneous adipose tissue. Low operational power and shielding requirements are achieved through the design of a permanent magnet array and surface transceiver coil. The sensor can acquire high signal-to-noise measurements in minutes, making it practical as a point-of-care tool for many quantitative diagnostic measurements, including T2 relaxometry. In this work, we present the in vitro and human in vivo performance of the device for muscle tissue evaluation.

Suggested Citation

  • Sydney E. Sherman & Alexa S. Zammit & Won-Seok Heo & Matthew S. Rosen & Michael J. Cima, 2024. "Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44561-9
    DOI: 10.1038/s41467-023-44561-9
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