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Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice

Author

Listed:
  • Toya Okonogi

    (The University of Tokyo)

  • Nahoko Kuga

    (Tohoku University)

  • Musashi Yamakawa

    (Tohoku University)

  • Tasuku Kayama

    (Tohoku University)

  • Yuji Ikegaya

    (The University of Tokyo
    The University of Tokyo
    National Institute of Information and Communications Technology, Suita City)

  • Takuya Sasaki

    (The University of Tokyo
    Tohoku University)

Abstract

The vagus nerve crucially affects emotions and psychiatric disorders. However, the detailed neurophysiological dynamics of the vagus nerve in response to emotions and its associated pathological changes remain unclear. In this study, we demonstrated that the spike rates of the cervical vagus nerve change depending on anxiety behavior in an elevated plus maze test, and these changes were eradicated in stress-susceptible male mice. Furthermore, instantaneous spike rates of the vagus nerve were negatively and positively correlated with the power of 2–4 Hz and 20–30 Hz oscillations, respectively, in the prefrontal cortex and amygdala. The oscillations also underwent dynamic changes depending on the behavioral state in the elevated plus maze, and these changes were no longer observed in stress-susceptible and vagotomized mice. Chronic vagus nerve stimulation restored behavior-relevant neuronal oscillations with the recovery of altered behavioral states in stress-susceptible mice. These results suggested that physiological vagal-brain communication underlies anxiety and mood disorders.

Suggested Citation

  • Toya Okonogi & Nahoko Kuga & Musashi Yamakawa & Tasuku Kayama & Yuji Ikegaya & Takuya Sasaki, 2024. "Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44205-y
    DOI: 10.1038/s41467-023-44205-y
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    References listed on IDEAS

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    1. Andrea N. Suarez & Ted M. Hsu & Clarissa M. Liu & Emily E. Noble & Alyssa M. Cortella & Emily M. Nakamoto & Joel D. Hahn & Guillaume Lartigue & Scott E. Kanoski, 2018. "Gut vagal sensory signaling regulates hippocampus function through multi-order pathways," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    2. Cyril Dejean & Julien Courtin & Nikolaos Karalis & Fabrice Chaudun & Hélène Wurtz & Thomas C. M. Bienvenu & Cyril Herry, 2016. "Prefrontal neuronal assemblies temporally control fear behaviour," Nature, Nature, vol. 535(7612), pages 420-424, July.
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