IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43842-7.html
   My bibliography  Save this article

Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine

Author

Listed:
  • Ryan S. Thwaites

    (Imperial College London)

  • Ashley S. S. Uruchurtu

    (Imperial College London)

  • Victor Augusti Negri

    (Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca)

  • Megan E. Cole

    (Imperial College London)

  • Nehmat Singh

    (Imperial College London)

  • Nelisa Poshai

    (Imperial College London)

  • David Jackson

    (United Kingdom Health Security Agency)

  • Katja Hoschler

    (United Kingdom Health Security Agency)

  • Tina Baker

    (Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca)

  • Ian C. Scott

    (Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca)

  • Xavier Romero Ros

    (Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca)

  • Emma Suzanne Cohen

    (Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca)

  • Maria Zambon

    (United Kingdom Health Security Agency)

  • Katrina M. Pollock

    (Imperial College London)

  • Trevor T. Hansel

    (Imperial College London)

  • Peter J. M. Openshaw

    (Imperial College London)

Abstract

Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens. Live attenuated influenza vaccine (LAIV) is effective in preventing influenza in children, but a correlate of protection for LAIV remains unclear. Studying young adult volunteers, we observe that LAIV induces distinct, compartmentalized, antibody responses in the mucosa and blood. Seeking immunologic correlates of these distinct antibody responses we find associations with mucosal IL-33 release in the first 8 hours post-inoculation and divergent CD8+ and circulating T follicular helper (cTfh) T cell responses 7 days post-inoculation. Mucosal antibodies are induced separately from blood antibodies, are associated with distinct immune responses early post-inoculation, and may provide a correlate of protection for mucosal vaccination. This study was registered as NCT04110366 and reports primary (mucosal antibody) and secondary (blood antibody, and nasal viral load and cytokine) endpoint data.

Suggested Citation

  • Ryan S. Thwaites & Ashley S. S. Uruchurtu & Victor Augusti Negri & Megan E. Cole & Nehmat Singh & Nelisa Poshai & David Jackson & Katja Hoschler & Tina Baker & Ian C. Scott & Xavier Romero Ros & Emma , 2023. "Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43842-7
    DOI: 10.1038/s41467-023-43842-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43842-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-43842-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43842-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.