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Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis

Author

Listed:
  • Long Zou

    (Wuhan University)

  • Siqi Xiang

    (Wuhan University)

  • Rui Sun

    (Wuhan University)

  • Qingquan Lu

    (Wuhan University)

Abstract

We report a combination of electrocatalysis and photoredox catalysis to perform selective C(sp3)–H arylation/alkylation of alkanes, in which a binary catalytic system based on earth-abundant iron and nickel is applied. Reaction selectivity between two-component C(sp3)–H arylation and three-component C(sp3)–H alkylation is tuned by modulating the applied current and light source. Importantly, an ultra-low anodic potential (~0.23 V vs. Ag/AgCl) is applied in this protocol, thus enabling compatibility with a variety of functional groups (>70 examples). The robustness of the method is further demonstrated on a preparative scale and applied to late-stage diversification of natural products and pharmaceutical derivatives.

Suggested Citation

  • Long Zou & Siqi Xiang & Rui Sun & Qingquan Lu, 2023. "Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43791-1
    DOI: 10.1038/s41467-023-43791-1
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