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DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration

Author

Listed:
  • Qi Yang

    (Rutgers University)

  • Xu Chang

    (Rutgers University)

  • Jung Yeon Lee

    (Rutgers University)

  • Minu Saji

    (Rutgers University)

  • Fei Zhang

    (Rutgers University)

Abstract

DNA tiles serve as the fundamental building blocks for DNA self-assembled nanostructures such as DNA arrays, origami, and designer crystals. Introducing additional binding arms to DNA crossover tiles holds the promise of unlocking diverse nano-assemblies and potential applications. Here, we present one-, two-, and three-layer T-shaped crossover tiles, by integrating T junction with antiparallel crossover tiles. These tiles carry over the orthogonal binding directions from T junction and retain the rigidity from antiparallel crossover tiles, enabling the assembly of various 2D tessellations. To demonstrate the versatility of the design rules, we create 2-state reconfigurable nanorings from both single-stranded tiles and single-unit assemblies. Moreover, four sets of 4-state reconfiguration systems are constructed, showing effective transformations between ladders and/or rings with pore sizes spanning ~20 nm to ~168 nm. These DNA tiles enrich the design tools in nucleic acid nanotechnology, offering exciting opportunities for the creation of artificial dynamic DNA nanopores.

Suggested Citation

  • Qi Yang & Xu Chang & Jung Yeon Lee & Minu Saji & Fei Zhang, 2023. "DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43558-8
    DOI: 10.1038/s41467-023-43558-8
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    References listed on IDEAS

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    1. Philip Ketterer & Adithya N. Ananth & Diederik S. Laman Trip & Ankur Mishra & Eva Bertosin & Mahipal Ganji & Jaco Torre & Patrick Onck & Hendrik Dietz & Cees Dekker, 2018. "DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    2. Tim Diederichs & Genevieve Pugh & Adam Dorey & Yongzheng Xing & Jonathan R. Burns & Quoc Hung Nguyen & Marc Tornow & Robert Tampé & Stefan Howorka, 2019. "Synthetic protein-conductive membrane nanopores built with DNA," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    3. Luvena L. Ong & Nikita Hanikel & Omar K. Yaghi & Casey Grun & Maximilian T. Strauss & Patrick Bron & Josephine Lai-Kee-Him & Florian Schueder & Bei Wang & Pengfei Wang & Jocelyn Y. Kishi & Cameron Myh, 2017. "Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components," Nature, Nature, vol. 552(7683), pages 72-77, December.
    4. Swarup Dey & Adam Dorey & Leeza Abraham & Yongzheng Xing & Irene Zhang & Fei Zhang & Stefan Howorka & Hao Yan, 2022. "A reversibly gated protein-transporting membrane channel made of DNA," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
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