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Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Author

Listed:
  • Zhentao Sang

    (China Medical University
    China Medical University)

  • Lu Xu

    (Shenyang Pharmaceutical University)

  • Renyu Ding

    (The First Hospital of China Medical University)

  • Minjun Wang

    (China Medical University)

  • Xiaoran Yang

    (China Medical University)

  • Xitan Li

    (The First Hospital of China Medical University)

  • Bingxin Zhou

    (China Medical University)

  • Kaijun Gou

    (The First Hospital of China Medical University)

  • Yang Han

    (Southwest Minzu University)

  • Tingting Liu

    (The First Hospital of China Medical University)

  • Xuchun Chen

    (The First Hospital of China Medical University)

  • Ying Cheng

    (The First Hospital of China Medical University)

  • Huazhe Yang

    (China Medical University)

  • Heran Li

    (China Medical University)

Abstract

The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nanospikes (VSN) to simulate viral morphology, and further modified VSN with L-alanine (CVSN) to enable chiral recognition for functional bionics. By comparing with the solid silica NPs, mesoporous silica NPs and VSN, we demonstrate the delivery advantages of CVSN on overcoming intestinal sequential barriers in both animals and human via multiple biological processes. Subsequently, we encapsulate indomethacin (IMC) into the nanopores of NPs to mimic gene package, wherein the payloads are isolated from bio-environments and exist in an amorphous form to increase their stability and solubility, while the chiral nanospikes multi-sited anchor and chiral recognize on the intestinal mucosa to enhance the penetrability and ultimately improve the oral adsorption of IMC. Encouragingly, we also prove the versatility of CVSN as oral Nano-DDS.

Suggested Citation

  • Zhentao Sang & Lu Xu & Renyu Ding & Minjun Wang & Xiaoran Yang & Xitan Li & Bingxin Zhou & Kaijun Gou & Yang Han & Tingting Liu & Xuchun Chen & Ying Cheng & Huazhe Yang & Heran Li, 2023. "Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43465-y
    DOI: 10.1038/s41467-023-43465-y
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    References listed on IDEAS

    as
    1. Ping Zhu & Jun Liu & Julian Bess & Elena Chertova & Jeffrey D. Lifson & Henry Grisé & Gilad A. Ofek & Kenneth A. Taylor & Kenneth H. Roux, 2006. "Distribution and three-dimensional structure of AIDS virus envelope spikes," Nature, Nature, vol. 441(7095), pages 847-852, June.
    2. Yan Cui & Hongyan Zhu & Jiandong Cai & Huibin Qiu, 2021. "Self-regulated co-assembly of soft and hard nanoparticles," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    3. Shankar Pandey & Shankar Mandal & Mathias Bogetoft Danielsen & Asha Brown & Changpeng Hu & Niels Johan Christensen & Alina Vitaliyivna Kulakova & Shixi Song & Tom Brown & Knud J. Jensen & Jesper Wenge, 2022. "Chirality transmission in macromolecular domains," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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