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Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application

Author

Listed:
  • Wenyan Ji

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    Tianjin University)

  • Pai Zhang

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Guangyuan Feng

    (Tianjin University)

  • Yuan-Zhe Cheng

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Tian-Xiong Wang

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Daqiang Yuan

    (Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (CAS))

  • Ruitao Cha

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Xuesong Ding

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Shengbin Lei

    (Tianjin University
    Tianjin University)

  • Bao-Hang Han

    (CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

Abstract

The topology type and the functionalization of pores play an important role in regulating the performance of covalent organic frameworks. Herein, we designed and synthesized the covalent organic framework with hetero-environmental pores using predesigned asymmetrical dialdehyde monomer. According to the results of structural characterization, crystallinity investigation, and theoretical calculation, the hetero-environmental pores of the obtained framework are regarded as the alternant arrangement. The distinctive hetero pore structure leads the designed material to show more advantages as compared with control materials in loading both hydrophobic and hydrophilic antibiotics for wound healing. This dual-antibiotic strategy can expand the antibacterial range as compared with the single antibiotic one, and reduce the generation of drug resistance. In summary, this strategy for designing covalent organic frameworks with hetero-environmental pores can extend the structural variety and provide a pathway for improving the practical application performance of these materials.

Suggested Citation

  • Wenyan Ji & Pai Zhang & Guangyuan Feng & Yuan-Zhe Cheng & Tian-Xiong Wang & Daqiang Yuan & Ruitao Cha & Xuesong Ding & Shengbin Lei & Bao-Hang Han, 2023. "Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41622-x
    DOI: 10.1038/s41467-023-41622-x
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    References listed on IDEAS

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    1. Tanmay Banerjee & Frederik Haase & Stefan Trenker & Bishnu P. Biswal & Gökcen Savasci & Viola Duppel & Igor Moudrakovski & Christian Ochsenfeld & Bettina V. Lotsch, 2019. "Sub-stoichiometric 2D covalent organic frameworks from tri- and tetratopic linkers," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Tanmay Banerjee & Frederik Haase & Stefan Trenker & Bishnu P. Biswal & Gökcen Savasci & Viola Duppel & Igor Moudrakovski & Christian Ochsenfeld & Bettina V. Lotsch, 2019. "Publisher Correction: Sub-stoichiometric 2D covalent organic frameworks from tri- and tetratopic linkers," Nature Communications, Nature, vol. 10(1), pages 1-1, December.
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