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Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Author

Listed:
  • Tsion Zewdu Minas

    (Center for Cancer Research, National Cancer Institute (NCI)
    Addis Ababa University)

  • Brittany D. Lord

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Amy L. Zhang

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Julián Candia

    (Center for Cancer Research, National Cancer Institute (NCI)
    Translational Gerontology Branch, National Institute on Aging)

  • Tiffany H. Dorsey

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Francine S. Baker

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Wei Tang

    (Center for Cancer Research, National Cancer Institute (NCI)
    Data Science & Artificial Intelligence, R&D, AstraZeneca)

  • Maeve Bailey-Whyte

    (Center for Cancer Research, National Cancer Institute (NCI)
    University of Limerick)

  • Cheryl J. Smith

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Obadi M. Obadi

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Anuoluwapo Ajao

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Symone V. Jordan

    (Center for Cancer Research, National Cancer Institute (NCI))

  • Yao Tettey

    (University of Ghana Medical School)

  • Richard B. Biritwum

    (University of Ghana Medical School)

  • Andrew A. Adjei

    (University of Ghana Medical School)

  • James E. Mensah

    (University of Ghana Medical School)

  • Robert N. Hoover

    (Division of Cancer Epidemiology & Genetics, NCI)

  • Ann W. Hsing

    (Stanford University
    Stanford University)

  • Jia Liu

    (Cancer Genomics Research Laboratory, NCI)

  • Christopher A. Loffredo

    (Georgetown University)

  • Clayton Yates

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Michael B. Cook

    (Division of Cancer Epidemiology & Genetics, NCI)

  • Stefan Ambs

    (Center for Cancer Research, National Cancer Institute (NCI))

Abstract

The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, suggesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders.

Suggested Citation

  • Tsion Zewdu Minas & Brittany D. Lord & Amy L. Zhang & Julián Candia & Tiffany H. Dorsey & Francine S. Baker & Wei Tang & Maeve Bailey-Whyte & Cheryl J. Smith & Obadi M. Obadi & Anuoluwapo Ajao & Symon, 2023. "Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39865-9
    DOI: 10.1038/s41467-023-39865-9
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    References listed on IDEAS

    as
    1. Rozenn N Lemaitre & Toshiko Tanaka & Weihong Tang & Ani Manichaikul & Millennia Foy & Edmond K Kabagambe & Jennifer A Nettleton & Irena B King & Lu-Chen Weng & Sayanti Bhattacharya & Stefania Bandinel, 2011. "Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium," PLOS Genetics, Public Library of Science, vol. 7(7), pages 1-12, July.
    2. Tsion Zewdu Minas & Julián Candia & Tiffany H. Dorsey & Francine Baker & Wei Tang & Maeve Kiely & Cheryl J. Smith & Amy L. Zhang & Symone V. Jordan & Obadi M. Obadi & Anuoluwapo Ajao & Yao Tettey & Ri, 2022. "Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

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