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A medullary hub for controlling REM sleep and pontine waves

Author

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  • Amanda L. Schott

    (University of Pennsylvania)

  • Justin Baik

    (University of Pennsylvania)

  • Shinjae Chung

    (University of Pennsylvania)

  • Franz Weber

    (University of Pennsylvania)

Abstract

Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are a hallmark of REM sleep implicated in memory consolidation. However, the brainstem circuits regulating P-waves, and their interactions with circuits generating REM sleep, remain largely unknown. Here, we show that an excitatory population of dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) regulates both REM sleep and P-waves in mice. Calcium imaging showed that dmM CRH neurons are selectively activated during REM sleep and recruited during P-waves, and opto- and chemogenetic experiments revealed that this population promotes REM sleep. Chemogenetic manipulation also induced prolonged changes in P-wave frequency, while brief optogenetic activation reliably triggered P-waves along with transiently accelerated theta oscillations in the electroencephalogram (EEG). Together, these findings anatomically and functionally delineate a common medullary hub for the regulation of both REM sleep and P-waves.

Suggested Citation

  • Amanda L. Schott & Justin Baik & Shinjae Chung & Franz Weber, 2023. "A medullary hub for controlling REM sleep and pontine waves," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39496-0
    DOI: 10.1038/s41467-023-39496-0
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    References listed on IDEAS

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    1. Lihui Lu & Yuqi Ren & Tao Yu & Zhixiang Liu & Sice Wang & Lubin Tan & Jiawei Zeng & Qiru Feng & Rui Lin & Yang Liu & Qingchun Guo & Minmin Luo, 2020. "Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Sung-Ho Park & Justin Baik & Jiso Hong & Hanna Antila & Benjamin Kurland & Shinjae Chung & Franz Weber, 2021. "A probabilistic model for the ultradian timing of REM sleep in mice," PLOS Computational Biology, Public Library of Science, vol. 17(8), pages 1-30, August.
    3. Juan F. Ramirez-Villegas & Michel Besserve & Yusuke Murayama & Henry C. Evrard & Axel Oeltermann & Nikos K. Logothetis, 2021. "Coupling of hippocampal theta and ripples with pontogeniculooccipital waves," Nature, Nature, vol. 589(7840), pages 96-102, January.
    4. C. Gutierrez Herrera & F. Girard & A. Bilella & T. C. Gent & D. M. Roccaro-Waldmeyer & A. Adamantidis & M. R. Celio, 2019. "Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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