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Tyrosine residues initiated photopolymerization in living organisms

Author

Listed:
  • Mei Zhu

    (Harbin Institute of Technology)

  • Shengliang Wang

    (Harbin Institute of Technology)

  • Zhenhui Li

    (Harbin Institute of Technology)

  • Junbo Li

    (Harbin Institute of Technology)

  • Zhijun Xu

    (Harbin Institute of Technology)

  • Xiaoman Liu

    (Harbin Institute of Technology)

  • Xin Huang

    (Harbin Institute of Technology)

Abstract

Towards intracellular engineering of living organisms, the development of new biocompatible polymerization system applicable for an intrinsically non-natural macromolecules synthesis for modulating living organism function/behavior is a key step. Herein, we find that the tyrosine residues in the cofactor-free proteins can be employed to mediate controlled radical polymerization under 405 nm light. A proton-coupled electron transfer (PCET) mechanism between the excited-state TyrOH* residue in proteins and the monomer or the chain transfer agent is confirmed. By using Tyr-containing proteins, a wide range of well-defined polymers are successfully generated. Especially, the developed photopolymerization system shows good biocompatibility, which can achieve in-situ extracellular polymerization from the surface of yeast cells for agglutination/anti-agglutination functional manipulation or intracellular polymerization inside yeast cells, respectively. Besides providing a universal aqueous photopolymerization system, this study should contribute a new way to generate various non-natural polymers in vitro or in vivo to engineer living organism functions and behaviours.

Suggested Citation

  • Mei Zhu & Shengliang Wang & Zhenhui Li & Junbo Li & Zhijun Xu & Xiaoman Liu & Xin Huang, 2023. "Tyrosine residues initiated photopolymerization in living organisms," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39286-8
    DOI: 10.1038/s41467-023-39286-8
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    References listed on IDEAS

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    1. Jordan J. Green & Jennifer H. Elisseeff, 2016. "Mimicking biological functionality with polymers for biomedical applications," Nature, Nature, vol. 540(7633), pages 386-394, December.
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    Cited by:

    1. Mengmeng Xia & Qiyue Wang & Yamin Liu & Chunyan Fang & Bo Zhang & Shengfei Yang & Fu Zhou & Peihua Lin & Mingzheng Gu & Canyu Huang & Xiaojun Zhang & Fangyuan Li & Hongying Liu & Guangfeng Wang & Dais, 2024. "Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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