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Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study

Author

Listed:
  • Qianli Wang

    (Fudan University)

  • Wei Wang

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Amy K. Winter

    (University of Georgia)

  • Zhifei Zhan

    (Hunan Provincial Center for Disease Control and Prevention)

  • Marco Ajelli

    (Indiana University School of Public Health)

  • Filippo Trentini

    (Bocconi University)

  • Lili Wang

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Fangcai Li

    (Hunan Provincial Center for Disease Control and Prevention)

  • Juan Yang

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Xingyu Xiang

    (Hunan Provincial Center for Disease Control and Prevention)

  • Qiaohong Liao

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Jiaxin Zhou

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Jinxin Guo

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Xuemei Yan

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • Nuolan Liu

    (Key Laboratory of Public Health Safety, Ministry of Education)

  • C. Jessica E. Metcalf

    (Princeton University
    Princeton University)

  • Bryan T. Grenfell

    (Princeton University
    Princeton University)

  • Hongjie Yu

    (Fudan University
    Key Laboratory of Public Health Safety, Ministry of Education)

Abstract

Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for 2.4 months. Following two-dose series of measles-containing vaccine (MCV) at 8 and 18 months of age, the immune protection against measles is not lifelong, and antibody concentrations are extrapolated to fall below the protective threshold of 200 mIU/ml at 14.3 years. A catch-up MCV dose in addition to the routine doses between 8 months and 5 years reduce the cumulative incidence of seroreversion by 79.3–88.7% by the age of 6 years. Our findings also support a good immune response after the first MCV vaccination at 8 months. These findings, coupled with the effectiveness of a catch-up dose in addition to the routine doses, could be instrumental to relevant stakeholders when planning routine immunization schedules and supplemental immunization activities.

Suggested Citation

  • Qianli Wang & Wei Wang & Amy K. Winter & Zhifei Zhan & Marco Ajelli & Filippo Trentini & Lili Wang & Fangcai Li & Juan Yang & Xingyu Xiang & Qiaohong Liao & Jiaxin Zhou & Jinxin Guo & Xuemei Yan & Nuo, 2023. "Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37407-x
    DOI: 10.1038/s41467-023-37407-x
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