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The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Author

Listed:
  • A. C. Gomes

    (Institute of Immunity & Transplantation, UCL)

  • I. A. Baraniak

    (Institute of Immunity & Transplantation, UCL)

  • A. Lankina

    (Institute of Immunity & Transplantation, UCL)

  • Z. Moulder

    (Institute of Immunity & Transplantation, UCL)

  • P. Holenya

    (JPT Peptide Technologies GmbH)

  • C. Atkinson

    (Institute of Immunity & Transplantation, UCL)

  • G. Tang

    (Institute of Immunity & Transplantation, UCL)

  • T. Mahungu

    (Institute of Immunity & Transplantation, UCL)

  • F. Kern

    (JPT Peptide Technologies GmbH
    Experimental Medicine, Brighton and Sussex Medical School)

  • P. D. Griffiths

    (Institute of Immunity & Transplantation, UCL)

  • M. B. Reeves

    (Institute of Immunity & Transplantation, UCL)

Abstract

Vaccination against human cytomegalovirus (CMV) infection remains high priority. A recombinant form of a protein essential for CMV entry, glycoprotein B (gB), demonstrated partial protection in a clinical trial (NCT00299260) when delivered with the MF59 adjuvant. Although the antibody titre against gB correlated with protection poor neutralising responses against the 5 known antigenic domains (AD) of gB were evident. Here, we show that vaccination of CMV seronegative patients induces an antibody response against a region of gB we term AD-6. Responses to the polypeptide AD-6 are detected in >70% of vaccine recipients yet in

Suggested Citation

  • A. C. Gomes & I. A. Baraniak & A. Lankina & Z. Moulder & P. Holenya & C. Atkinson & G. Tang & T. Mahungu & F. Kern & P. D. Griffiths & M. B. Reeves, 2023. "The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36683-x
    DOI: 10.1038/s41467-023-36683-x
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