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Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Author

Listed:
  • Junhua Xu

    (Indiana University
    Biopharmaceutical Research Institute, West China Hospital, Sichuan University)

  • Hongwei Cai

    (Indiana University)

  • Zhuhao Wu

    (Indiana University)

  • Xiang Li

    (Indiana University)

  • Chunhui Tian

    (Indiana University)

  • Zheng Ao

    (Indiana University)

  • Vivian C. Niu

    (Indiana University
    Bloomington High School South)

  • Xiao Xiao

    (University of California, Los Angeles)

  • Lei Jiang

    (Indiana University)

  • Marat Khodoun

    (University of Cincinnati)

  • Marc Rothenberg

    (University of Cincinnati)

  • Ken Mackie

    (Indiana University)

  • Jun Chen

    (University of California, Los Angeles)

  • Luke P. Lee

    (Brigham and Women’s Hospital, Harvard Medical School
    University of California at Berkeley
    Sungkyunkwan University)

  • Feng Guo

    (Indiana University)

Abstract

Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard ‘self-injectable epinephrine’ strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.

Suggested Citation

  • Junhua Xu & Hongwei Cai & Zhuhao Wu & Xiang Li & Chunhui Tian & Zheng Ao & Vivian C. Niu & Xiao Xiao & Lei Jiang & Marat Khodoun & Marc Rothenberg & Ken Mackie & Jun Chen & Luke P. Lee & Feng Guo, 2023. "Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36581-2
    DOI: 10.1038/s41467-023-36581-2
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    References listed on IDEAS

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    1. Simon Makin, 2019. "The emerging world of digital therapeutics," Nature, Nature, vol. 573(7775), pages 106-109, September.
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