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An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery

Author

Listed:
  • Yan Zhou

    (Jilin University)

  • Xiaoteng Jia

    (Jilin University)

  • Daxin Pang

    (Jilin University)

  • Shan Jiang

    (Jilin University)

  • Meihua Zhu

    (Jilin University)

  • Geyu Lu

    (Jilin University
    Jilin University)

  • Yaping Tian

    (The First Hospital of Jilin University)

  • Caiyun Wang

    (University of Wollongong)

  • Danming Chao

    (Jilin University)

  • Gordon Wallace

    (University of Wollongong)

Abstract

Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages for patient-comfort when deploying epidermal diseases treatments. However, current self-powered iontophoresis based on energy harvesters is limited to support efficient therapeutic administration over the long-term operation, owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug reservoir and cathode material, eliminating the conventional interface impedance between the electrode and drug reservoir. The redox-active polyelectrolyte hydrogel offers a high energy density of 3.57 mWh cm−2, and an optimal bioelectronic interface with ultra-soft nature and low tissue-interface impedance. The delivery dosage can be readily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode. This iontophoresis patch demonstrates an effective treatment of an imiquimod-induced psoriasis mouse. Considering the advantages of being a reliable and efficient energy supply, simplified configuration, and optimal electrical skin-device interface, this battery-powered iontophoresis may provide a new non-invasive treatment for chronic epidermal diseases.

Suggested Citation

  • Yan Zhou & Xiaoteng Jia & Daxin Pang & Shan Jiang & Meihua Zhu & Geyu Lu & Yaping Tian & Caiyun Wang & Danming Chao & Gordon Wallace, 2023. "An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35990-7
    DOI: 10.1038/s41467-023-35990-7
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    References listed on IDEAS

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    1. Samantha M. Grist & Andoni P. Mourdoukoutas & Amy E. Herr, 2020. "3D projection electrophoresis for single-cell immunoblotting," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    2. Peter Zanvit & Joanne E. Konkel & Xue Jiao & Shimpei Kasagi & Dunfang Zhang & Ruiqing Wu & Cheryl Chia & Nadim J. Ajami & Daniel P. Smith & Joseph F. Petrosino & Brittany Abbatiello & Hiroko Nakatsuka, 2015. "Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis," Nature Communications, Nature, vol. 6(1), pages 1-10, December.
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