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Neural precursor cells tune striatal connectivity through the release of IGFBPL1

Author

Listed:
  • Erica Butti

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital)

  • Stefano Cattaneo

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
    Vita-Salute San Raffaele University)

  • Marco Bacigaluppi

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
    Vita-Salute San Raffaele University)

  • Marco Cambiaghi

    (University of Verona)

  • Giulia Maria Scotti

    (IRCCS San Raffaele Hospital)

  • Elena Brambilla

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital)

  • Francesca Ruffini

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital)

  • Giacomo Sferruzza

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital)

  • Maddalena Ripamonti

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
    Vita-Salute San Raffaele University)

  • Fabio Simeoni

    (IRCCS San Raffaele Hospital)

  • Laura Cacciaguerra

    (Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital)

  • Aurora Zanghì

    (Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital)

  • Angelo Quattrini

    (Division of Neuroscience, IRCCS San Raffaele Hospital)

  • Riccardo Fesce

    (Humanitas University, Pieve Emanuele)

  • Paola Panina-Bordignon

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
    Vita-Salute San Raffaele University)

  • Francesca Giannese

    (IRCCS San Raffaele Hospital)

  • Davide Cittaro

    (IRCCS San Raffaele Hospital)

  • Tanja Kuhlmann

    (University Hospital Muster)

  • Patrizia D’Adamo

    (Division of Neuroscience, IRCCS San Raffaele Hospital)

  • Maria Assunta Rocca

    (Vita-Salute San Raffaele University
    Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Hospital)

  • Stefano Taverna

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital)

  • Gianvito Martino

    (Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Hospital
    Vita-Salute San Raffaele University)

Abstract

The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.

Suggested Citation

  • Erica Butti & Stefano Cattaneo & Marco Bacigaluppi & Marco Cambiaghi & Giulia Maria Scotti & Elena Brambilla & Francesca Ruffini & Giacomo Sferruzza & Maddalena Ripamonti & Fabio Simeoni & Laura Cacci, 2022. "Neural precursor cells tune striatal connectivity through the release of IGFBPL1," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35341-y
    DOI: 10.1038/s41467-022-35341-y
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