IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-33867-9.html
   My bibliography  Save this article

The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial

Author

Listed:
  • Ravi Retnakaran

    (Mount Sinai Hospital
    University of Toronto
    Mount Sinai Hospital)

  • Chang Ye

    (Mount Sinai Hospital)

  • Alexandra Emery

    (Mount Sinai Hospital)

  • Caroline K. Kramer

    (Mount Sinai Hospital
    University of Toronto
    Mount Sinai Hospital)

  • Bernard Zinman

    (Mount Sinai Hospital
    University of Toronto
    Mount Sinai Hospital)

Abstract

Combining a glucagon-like peptide-1 receptor agonist (GLP1-RA) with basal insulin is an emerging option when initiating injectable therapy in longstanding type 2 diabetes (T2DM). Recognizing that short-term insulin therapy can improve beta-cell function and induce glycemic remission in early T2DM, we hypothesized that adding the short-acting GLP1-RA exenatide to basal insulin in early T2DM may enhance the achievability of these outcomes. In this completed, 20-week, open-label, parallel-arm trial at an academic hospital, 103 individuals aged 30–80 years with

Suggested Citation

  • Ravi Retnakaran & Chang Ye & Alexandra Emery & Caroline K. Kramer & Bernard Zinman, 2022. "The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33867-9
    DOI: 10.1038/s41467-022-33867-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-33867-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-33867-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ravi Retnakaran & Jiajie Pu & Alexandra Emery & Stewart B. Harris & Sonja M. Reichert & Hertzel C. Gerstein & Natalia McInnes & Caroline K. Kramer & Bernard Zinman, 2023. "Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33867-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.