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Long-term whole blood DNA preservation by cost-efficient cryosilicification

Author

Listed:
  • Liang Zhou

    (South China University of Technology)

  • Qi Lei

    (South China University of Technology)

  • Jimin Guo

    (The University of New Mexico)

  • Yuanyuan Gao

    (South China University of Technology)

  • Jianjun Shi

    (Science and Technology on Advanced Functional Composites Technology, Aerospace Research Institute of Materials & Processing Technology)

  • Hong Yu

    (South China University of Technology)

  • Wenxiang Yin

    (South China University of Technology)

  • Jiangfan Cao

    (South China University of Technology)

  • Botao Xiao

    (South China University of Technology)

  • Jacopo Andreo

    (BCMaterials, Basque Center for Materials, UPV/EHU Science Park)

  • Romy Ettlinger

    (University of St. Andrews)

  • C. Jeffrey Brinker

    (The University of New Mexico)

  • Stefan Wuttke

    (BCMaterials, Basque Center for Materials, UPV/EHU Science Park
    Ikerbasque, Basque Foundation for Science)

  • Wei Zhu

    (South China University of Technology)

Abstract

Deoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/person. Additionally, our demonstration of 3D-printed DNA banking artefacts, could potentially allow ‘artificial fossilization’.

Suggested Citation

  • Liang Zhou & Qi Lei & Jimin Guo & Yuanyuan Gao & Jianjun Shi & Hong Yu & Wenxiang Yin & Jiangfan Cao & Botao Xiao & Jacopo Andreo & Romy Ettlinger & C. Jeffrey Brinker & Stefan Wuttke & Wei Zhu, 2022. "Long-term whole blood DNA preservation by cost-efficient cryosilicification," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33759-y
    DOI: 10.1038/s41467-022-33759-y
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