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Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models

Author

Listed:
  • Ani Baghdasaryan

    (Stanford University)

  • Feifei Wang

    (Stanford University)

  • Fuqiang Ren

    (Stanford University)

  • Zhuoran Ma

    (Stanford University)

  • Jiachen Li

    (Stanford University)

  • Xueting Zhou

    (Stanford University)

  • Lilit Grigoryan

    (Stanford University)

  • Chun Xu

    (Stanford University)

  • Hongjie Dai

    (Stanford University)

Abstract

Sentinel lymph node imaging and biopsy is important to clinical assessment of cancer metastasis, and novel non-radioactive lymphographic tracers have been actively pursued over the years. Here, we develop gold molecular clusters (Au25) functionalized by phosphorylcholine (PC) ligands for NIR-II (1000–3000 nm) fluorescence imaging of draining lymph nodes in 4T1 murine breast cancer and CT26 colon cancer tumor mouse models. The Au-phosphorylcholine (Au-PC) probes exhibit ‘super-stealth’ behavior with little interactions with serum proteins, cells and tissues in vivo, which differs from the indocyanine green (ICG) dye. Subcutaneous injection of Au-PC allows lymph node mapping by NIR-II fluorescence imaging at an optimal time of ~ 0.5 − 1 hour postinjection followed by rapid renal clearance. Preclinical NIR-II fluorescence LN imaging with Au-PC affords high signal to background ratios and high safety and biocompatibility, promising for future clinical translation.

Suggested Citation

  • Ani Baghdasaryan & Feifei Wang & Fuqiang Ren & Zhuoran Ma & Jiachen Li & Xueting Zhou & Lilit Grigoryan & Chun Xu & Hongjie Dai, 2022. "Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33341-6
    DOI: 10.1038/s41467-022-33341-6
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    References listed on IDEAS

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    1. Yuanyuan Li & Zhaochong Cai & Shunjie Liu & Haoke Zhang & Sherman T. H. Wong & Jacky W. Y. Lam & Ryan T. K. Kwok & Jun Qian & Ben Zhong Tang, 2020. "Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Michael G. Taylor & Giannis Mpourmpakis, 2017. "Thermodynamic stability of ligand-protected metal nanoclusters," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
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