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Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection

Author

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  • Yonatan Woodbridge

    (Sheba Medical Center
    Holon Institute of Technology)

  • Sharon Amit

    (Sheba Medical Center)

  • Amit Huppert

    (Sheba Medical Center
    Sackler Faculty of Medicine, Tel-Aviv University)

  • Naama M. Kopelman

    (Holon Institute of Technology)

Abstract

An important aspect of vaccine effectiveness is its impact on pathogen transmissibility, harboring major implications for public health policies. As viral load is a prominent factor affecting infectivity, its laboratory surrogate, qRT-PCR cycle threshold (Ct), can be used to investigate the infectivity-related component of vaccine effectiveness. While vaccine waning has previously been observed for viral load during the Delta wave, less is known regarding how Omicron viral load is affected by vaccination status, and whether vaccine-derived and natural infection protection are sustained. By analyzing results of more than 460,000 individuals, we show that while recent vaccination reduces Omicron viral load, its effect wanes rapidly. In contrast, a significantly slower waning rate is demonstrated for recovered COVID-19 individuals. Thus, while the vaccine is effective in decreasing morbidity and mortality, its relatively small effect on transmissibility of Omicron (as measured here by Ct) and its rapid waning call for reassessment of future booster campaigns.

Suggested Citation

  • Yonatan Woodbridge & Sharon Amit & Amit Huppert & Naama M. Kopelman, 2022. "Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33096-0
    DOI: 10.1038/s41467-022-33096-0
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    1. Matan Levine-Tiefenbrun & Idan Yelin & Hillel Alapi & Esma Herzel & Jacob Kuint & Gabriel Chodick & Sivan Gazit & Tal Patalon & Roy Kishony, 2022. "Waning of SARS-CoV-2 booster viral-load reduction effectiveness," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
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    1. Denis Mongin & Nils Bürgisser & Gustavo Laurie & Guillaume Schimmel & Diem-Lan Vu & Stephane Cullati & Delphine Sophie Courvoisier, 2023. "Effect of SARS-CoV-2 prior infection and mRNA vaccination on contagiousness and susceptibility to infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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