IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31947-4.html
   My bibliography  Save this article

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

Author

Listed:
  • André A. Weber

    (University of California, San Diego)

  • Xiaojing Yang

    (University of California, San Diego)

  • Elvira Mennillo

    (University of California, San Diego)

  • Jeffrey Ding

    (University of California, San Diego)

  • Jeramie D. Watrous

    (University of California, San Diego)

  • Mohit Jain

    (University of California, San Diego)

  • Shujuan Chen

    (University of California, San Diego)

  • Michael Karin

    (University of California, San Diego)

  • Robert H. Tukey

    (University of California, San Diego)

Abstract

Here we show that Triclosan (TCS), a high-volume antimicrobial additive that has been detected in human breastmilk, can be efficiently transferred by lactation to newborn mice, causing significant fatty liver (FL) during the suckling period. These findings are relevant since pediatric non-alcoholic fatty liver disease (NAFLD) is escalating in the United States, with a limited mechanistic understanding. Lactational delivery stimulated hepatosteatosis, triglyceride accumulation, endoplasmic reticulum (ER) stress, signs of inflammation, and liver fibrosis. De novo lipogenesis (DNL) induced by lactational TCS exposure is shown to be mediated in a PERK-eIF2α-ATF4-PPARα cascade. The administration of obeticholic acid (OCA), a potent FXR agonist, as well as activation of intestinal mucosal-regenerative gp130 signaling, led to reduced liver ATF4 expression, PPARα signaling, and DNL when neonates were exposed to TCS. It is yet to be investigated but mother to child transmission of TCS or similar toxicants may underlie the recent increases in pediatric NAFLD.

Suggested Citation

  • André A. Weber & Xiaojing Yang & Elvira Mennillo & Jeffrey Ding & Jeramie D. Watrous & Mohit Jain & Shujuan Chen & Michael Karin & Robert H. Tukey, 2022. "Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31947-4
    DOI: 10.1038/s41467-022-31947-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31947-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31947-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jianan Zhang & Morgan E. Walker & Katherine Z. Sanidad & Hongna Zhang & Yanshan Liang & Ermin Zhao & Katherine Chacon-Vargas & Vladimir Yeliseyev & Julie Parsonnet & Thomas D. Haggerty & Guangqiang Wa, 2022. "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Pere Puigserver & James Rhee & Jerry Donovan & Christopher J. Walkey & J. Cliff Yoon & Francesco Oriente & Yukari Kitamura & Jennifer Altomonte & Hengjiang Dong & Domenico Accili & Bruce M. Spiegelman, 2003. "Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction," Nature, Nature, vol. 423(6939), pages 550-555, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huanqing Gao & Liang Zhou & Yiming Zhong & Zhen Ding & Sixiong Lin & Xiaoting Hou & Xiaoqian Zhou & Jie Shao & Fan Yang & Xuenong Zou & Huiling Cao & Guozhi Xiao, 2022. "Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ewa Bielczyk-Maczynska & Meng Zhao & Peter-James H. Zushin & Theresia M. Schnurr & Hyun-Jung Kim & Jiehan Li & Pratima Nallagatla & Panjamaporn Sangwung & Chong Y. Park & Cameron Cornn & Andreas Stahl, 2022. "G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31947-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.