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Thalamo-hippocampal pathway regulates incidental memory capacity in mice

Author

Listed:
  • G. Torromino

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • V. Loffredo

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council
    Sapienza University of Rome)

  • D. Cavezza

    (Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • G. Sonsini

    (Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • F. Esposito

    (Telethon Institute of Genetics and Medicine, Telethon Foundation)

  • A. H. Crevenna

    (Neurobiology and Epigenetics Unit, European Molecular Biology Laboratory (EMBL))

  • M. Gioffrè

    (Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council)

  • M. De Risi

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

  • A. Treves

    (SISSA - Cognitive Neuroscience)

  • M. Griguoli

    (European Brain Research Institute (EBRI)
    Institute of Molecular Biology and Pathology (IBPM), National Research Council)

  • E. De Leonibus

    (Telethon Institute of Genetics and Medicine, Telethon Foundation
    Institute of Biochemistry and Cell Biology (IBBC), National Research Council)

Abstract

Incidental memory can be challenged by increasing either the retention delay or the memory load. The dorsal hippocampus (dHP) appears to help with both consolidation from short-term (STM) to long-term memory (LTM), and higher memory loads, but the mechanism is not fully understood. Here we find that female mice, despite having the same STM capacity of 6 objects and higher resistance to distraction in our different object recognition task (DOT), when tested over 1 h or 24 h delays appear to transfer to LTM only 4 objects, whereas male mice have an STM capacity of 6 objects in this task. In male mice the dHP shows greater activation (as measured by c-Fos expression), whereas female mice show greater activation of the ventral midline thalamus (VMT). Optogenetic inhibition of the VMT-dHP pathway during off-line memory consolidation enables 6-object LTM retention in females, while chemogenetic VMT-activation impairs it in males. Thus, removing or enhancing sub-cortical inhibitory control over the hippocampus leads to differences in incidental memory.

Suggested Citation

  • G. Torromino & V. Loffredo & D. Cavezza & G. Sonsini & F. Esposito & A. H. Crevenna & M. Gioffrè & M. De Risi & A. Treves & M. Griguoli & E. De Leonibus, 2022. "Thalamo-hippocampal pathway regulates incidental memory capacity in mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31781-8
    DOI: 10.1038/s41467-022-31781-8
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    References listed on IDEAS

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    1. Vijendra Sharma & Rapita Sood & Abdessattar Khlaifia & Mohammad Javad Eslamizade & Tzu-Yu Hung & Danning Lou & Azam Asgarihafshejani & Maya Lalzar & Stephen J. Kiniry & Matthew P. Stokes & Noah Cohen , 2020. "eIF2α controls memory consolidation via excitatory and somatostatin neurons," Nature, Nature, vol. 586(7829), pages 412-416, October.
    2. Hiroshi T. Ito & Sheng-Jia Zhang & Menno P. Witter & Edvard I. Moser & May-Britt Moser, 2015. "A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation," Nature, Nature, vol. 522(7554), pages 50-55, June.
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