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Conformational heterogeneity of molecules physisorbed on a gold surface at room temperature

Author

Listed:
  • Mingu Kang

    (Pohang University of Science and Technology (POSTECH)
    Ulsan National Institute of Science and Technology (UNIST))

  • Hyunwoo Kim

    (Korea Research Institute of Chemical Technology (KRICT))

  • Elham Oleiki

    (Ulsan National Institute of Science and Technology (UNIST))

  • Yeonjeong Koo

    (Pohang University of Science and Technology (POSTECH)
    Ulsan National Institute of Science and Technology (UNIST))

  • Hyeongwoo Lee

    (Pohang University of Science and Technology (POSTECH)
    Ulsan National Institute of Science and Technology (UNIST))

  • Huitae Joo

    (Ulsan National Institute of Science and Technology (UNIST))

  • Jinseong Choi

    (Ulsan National Institute of Science and Technology (UNIST))

  • Taeyong Eom

    (Korea Research Institute of Chemical Technology (KRICT))

  • Geunsik Lee

    (Ulsan National Institute of Science and Technology (UNIST))

  • Yung Doug Suh

    (Korea Research Institute of Chemical Technology (KRICT)
    Ulsan National Institute of Science and Technology (UNIST)
    Ulsan National Institute of Science and Technology (UNIST))

  • Kyoung-Duck Park

    (Pohang University of Science and Technology (POSTECH)
    Ulsan National Institute of Science and Technology (UNIST))

Abstract

A quantitative single-molecule tip-enhanced Raman spectroscopy (TERS) study at room temperature remained a challenge due to the rapid structural dynamics of molecules exposed to air. Here, we demonstrate the hyperspectral TERS imaging of single or a few brilliant cresyl blue (BCB) molecules at room temperature, along with quantitative spectral analyses. Robust chemical imaging is enabled by the freeze-frame approach using a thin Al2O3 capping layer, which suppresses spectral diffusions and inhibits chemical reactions and contamination in air. For the molecules resolved spatially in the TERS image, a clear Raman peak variation up to 7.5 cm−1 is observed, which cannot be found in molecular ensembles. From density functional theory-based quantitative analyses of the varied TERS peaks, we reveal the conformational heterogeneity at the single-molecule level. This work provides a facile way to investigate the single-molecule properties in interacting media, expanding the scope of single-molecule vibrational spectroscopy studies.

Suggested Citation

  • Mingu Kang & Hyunwoo Kim & Elham Oleiki & Yeonjeong Koo & Hyeongwoo Lee & Huitae Joo & Jinseong Choi & Taeyong Eom & Geunsik Lee & Yung Doug Suh & Kyoung-Duck Park, 2022. "Conformational heterogeneity of molecules physisorbed on a gold surface at room temperature," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31576-x
    DOI: 10.1038/s41467-022-31576-x
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    References listed on IDEAS

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    Cited by:

    1. Wenhao Fu & Huanyu Chi & Xin Dai & Hongni Zhu & Vince St. Dollente Mesias & Wei Liu & Jinqing Huang, 2023. "Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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