IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31201-x.html
   My bibliography  Save this article

Innate immune responses against the fungal pathogen Candida auris

Author

Listed:
  • Yuanyuan Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Yun Zou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Xiaoqing Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hao Li

    (Shanghai Jiao Tong University School of Medicine)

  • Zhe Yin

    (Beijing Institute of Microbiology and Epidemiology)

  • Baocai Zhang

    (Chinese Academy of Sciences)

  • Yongbin Xu

    (Shanghai University of Traditional Chinese Medicine)

  • Yiquan Zhang

    (Jiangnan University)

  • Rulin Zhang

    (Shanghai Jiao Tong University School of Medicine)

  • Xinhua Huang

    (Chinese Academy of Sciences)

  • Wenhui Yang

    (Beijing Institute of Microbiology and Epidemiology)

  • Chaoyue Xu

    (Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health
    Shanghai University)

  • Tong Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Qinyu Tang

    (Tongji University School of Medicine)

  • Zili Zhou

    (Chinese Academy of Sciences)

  • Ying Ji

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yingqi Liu

    (Gannan Medical University)

  • Lingfei Hu

    (Beijing Institute of Microbiology and Epidemiology)

  • Jia Zhou

    (Shanghai Jiaotong University School of Medicine)

  • Yao Zhou

    (Guangxi Academy of Sciences)

  • Jingjun Zhao

    (Tongji University School of Medicine)

  • Ningning Liu

    (Shanghai Jiaotong University School of Medicine)

  • Guanghua Huang

    (Fudan University)

  • Haishuang Chang

    (Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine)

  • Wenxia Fang

    (Guangxi Academy of Sciences)

  • Changbin Chen

    (Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Dongsheng Zhou

    (Beijing Institute of Microbiology and Epidemiology)

Abstract

Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.

Suggested Citation

  • Yuanyuan Wang & Yun Zou & Xiaoqing Chen & Hao Li & Zhe Yin & Baocai Zhang & Yongbin Xu & Yiquan Zhang & Rulin Zhang & Xinhua Huang & Wenhui Yang & Chaoyue Xu & Tong Jiang & Qinyu Tang & Zili Zhou & Yi, 2022. "Innate immune responses against the fungal pathogen Candida auris," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31201-x
    DOI: 10.1038/s41467-022-31201-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31201-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31201-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jian Bing & Zhangyue Guan & Tianhong Zheng & Craig L. Ennis & Clarissa J. Nobile & Changbin Chen & Haiqing Chu & Guanghua Huang, 2024. "Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31201-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.