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Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict

Author

Listed:
  • Dylan C. M. Yeates

    (University of Toronto)

  • Dallas Leavitt

    (University of Toronto)

  • Sajeevan Sujanthan

    (University of Toronto)

  • Nisma Khan

    (University of Toronto)

  • Denada Alushaj

    (University of Toronto)

  • Andy C. H. Lee

    (University of Toronto
    Baycrest Centre)

  • Rutsuko Ito

    (University of Toronto
    University of Toronto)

Abstract

The ability to resolve an approach-avoidance conflict is critical to adaptive behavior. The ventral CA3 (vCA3) and CA1 (vCA1) subfields of the ventral hippocampus (vHPC) have been shown to facilitate avoidance and approach behavior, respectively, in the face of motivational conflict, but the neural circuits by which this subfield-specific regulation is implemented is unknown. We demonstrate that two distinct pathways from these subfields to lateral septum (LS) contribute to this divergent control. In Long-Evans rats, chemogenetic inhibition of the vCA3- LS caudodorsal (cd) pathway potentiated approach towards a learned conflict-eliciting stimulus, while inhibition of the vCA1-LS rostroventral (rv) pathway potentiated approach non-specifically. Additionally, vCA3-LScd inhibited animals were less hesitant to explore food during environmental uncertainty, while the vCA1- LSrv inhibited animals took longer to initiate food exploration. These findings suggest that the vHPC influences multiple behavioral systems via differential projections to the LS, which in turn send inhibitory projections to motivational centres of the brain.

Suggested Citation

  • Dylan C. M. Yeates & Dallas Leavitt & Sajeevan Sujanthan & Nisma Khan & Denada Alushaj & Andy C. H. Lee & Rutsuko Ito, 2022. "Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31082-0
    DOI: 10.1038/s41467-022-31082-0
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    References listed on IDEAS

    as
    1. Patrick Sweeney & Yunlei Yang, 2015. "An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    2. Yuanzhong Xu & Yungang Lu & Ryan M. Cassidy & Leandra R. Mangieri & Canjun Zhu & Xugen Huang & Zhiying Jiang & Nicholas J. Justice & Yong Xu & Benjamin R. Arenkiel & Qingchun Tong, 2019. "Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    3. Ming-Dao Mu & Hong-Yan Geng & Kang-Lin Rong & Rong-Chao Peng & Shu-Ting Wang & Lin-Ting Geng & Zhong-Ming Qian & Wing-Ho Yung & Ya Ke, 2020. "A limbic circuitry involved in emotional stress-induced grooming," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    4. Ann M. Clemens & Hong Wang & Michael Brecht, 2020. "The lateral septum mediates kinship behavior in the rat," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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