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Metabolic regulation by the intestinal metformin-AMPK axis

Author

Listed:
  • Song-Yang Zhang

    (Toronto General Hospital Research Institute, UHN)

  • Tony K. T. Lam

    (Toronto General Hospital Research Institute, UHN
    University of Toronto
    University of Toronto
    University of Toronto)

Abstract

AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to metformin and exhibit disruption in metabolic homeostasis secondary to changes in the gut microbiome. This highlights a therapeutic potential of targeting intestinal AMPK for diabetes.

Suggested Citation

  • Song-Yang Zhang & Tony K. T. Lam, 2022. "Metabolic regulation by the intestinal metformin-AMPK axis," Nature Communications, Nature, vol. 13(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30477-3
    DOI: 10.1038/s41467-022-30477-3
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    References listed on IDEAS

    as
    1. Eryun Zhang & Lihua Jin & Yangmeng Wang & Jui Tu & Ruirong Zheng & Lili Ding & Zhipeng Fang & Mingjie Fan & Ismail Al-Abdullah & Rama Natarajan & Ke Ma & Zhengtao Wang & Arthur D. Riggs & Sarah C. Shu, 2022. "Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Russell A. Miller & Qingwei Chu & Jianxin Xie & Marc Foretz & Benoit Viollet & Morris J. Birnbaum, 2013. "Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP," Nature, Nature, vol. 494(7436), pages 256-260, February.
    3. Frank A. Duca & T. M. Zaved Waise & Willem T. Peppler & Tony K. T. Lam, 2021. "The metabolic impact of small intestinal nutrient sensing," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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