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Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development

Author

Listed:
  • Thomas Jamnik

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology)

  • Mira Flasch

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology)

  • Dominik Braun

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology)

  • Yasmin Fareed

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology)

  • Daniel Wasinger

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology)

  • David Seki

    (Comprehensive Center for Pediatrics
    Division of Microbial Ecology, University of Vienna)

  • David Berry

    (Division of Microbial Ecology, University of Vienna)

  • Angelika Berger

    (Comprehensive Center for Pediatrics)

  • Lukas Wisgrill

    (Comprehensive Center for Pediatrics
    Exposome Austria, Research Infrastructure and National EIRENE Hub)

  • Benedikt Warth

    (University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
    Exposome Austria, Research Infrastructure and National EIRENE Hub)

Abstract

Exposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatography-tandem mass spectrometry approach was developed and validated. The assay enables the analysis of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL−1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method’s applicability for large-scale exposomics-type cohort studies.

Suggested Citation

  • Thomas Jamnik & Mira Flasch & Dominik Braun & Yasmin Fareed & Daniel Wasinger & David Seki & David Berry & Angelika Berger & Lukas Wisgrill & Benedikt Warth, 2022. "Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30204-y
    DOI: 10.1038/s41467-022-30204-y
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