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Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy

Author

Listed:
  • Minglun Liu

    (Nanjing University)

  • Yuncong Chen

    (Nanjing University
    Nanchuang (Jiangsu) Institute of Chemistry and Health)

  • Yan Guo

    (Nanjing University)

  • Hao Yuan

    (Nanjing University)

  • Tongxiao Cui

    (Nanjing University)

  • Shankun Yao

    (Nanjing University)

  • Suxing Jin

    (Nanjing University)

  • Huanhuan Fan

    (Nanjing University)

  • Chengjun Wang

    (Sinopec Shengli Petroleum Engineering Limited Company)

  • Ran Xie

    (Nanjing University)

  • Weijiang He

    (Nanjing University
    Nanchuang (Jiangsu) Institute of Chemistry and Health)

  • Zijian Guo

    (Nanjing University
    Nanchuang (Jiangsu) Institute of Chemistry and Health)

Abstract

Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (PDT). However, due to the lack of effective design strategy, photosensitizers (PSs) with specific GA targeting ability are in high demand and yet quite challenging. Herein, we report an aggregation-induced emission luminogen (AIEgen) based PS (TPE-PyT-CPS) that can effectively target the GA via caveolin/raft mediated endocytosis with a Pearson correlation coefficient up to 0.98. Additionally, the introduction of pyrene into TPE-PyT-CPS can reduce the energy gap between the lowest singlet state (S1) and the lowest triplet state (T1) (ΔEST) and exhibits enhanced singlet oxygen generation capability. GA fragmentation and cleavage of GA proteins (p115/GM130) are observed upon light irradiation. Meanwhile, the apoptotic pathway is activated through a crosstalk between GA oxidative stress and mitochondria in HeLa cells. More importantly, GA targeting TPE-T-CPS show better PDT effect than its non-GA-targeting counterpart TPE-PyT-PS, even though they possess very close ROS generation rate. This work provides a strategy for the development of PSs with specific GA targeting ability, which is of great importance for precise and effective PDT.

Suggested Citation

  • Minglun Liu & Yuncong Chen & Yan Guo & Hao Yuan & Tongxiao Cui & Shankun Yao & Suxing Jin & Huanhuan Fan & Chengjun Wang & Ran Xie & Weijiang He & Zijian Guo, 2022. "Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29872-7
    DOI: 10.1038/s41467-022-29872-7
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    References listed on IDEAS

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    1. Wenjia Zhang & Xianglong Hu & Qi Shen & Da Xing, 2019. "Author Correction: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy," Nature Communications, Nature, vol. 10(1), pages 1-1, December.
    2. Wei Li & Jie Yang & Lihua Luo & Mengshi Jiang & Bing Qin & Hang Yin & Chunqi Zhu & Xiaoling Yuan & Junlei Zhang & Zhenyu Luo & Yongzhong Du & Qingpo Li & Yan Lou & Yunqing Qiu & Jian You, 2019. "Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    3. Wenjia Zhang & Xianglong Hu & Qi Shen & Da Xing, 2019. "Author Correction: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy," Nature Communications, Nature, vol. 10(1), pages 1-2, December.
    4. Wenjia Zhang & Xianglong Hu & Qi Shen & Da Xing, 2019. "Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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    Cited by:

    1. Liang Zhang & An Song & Qi-Chao Yang & Shu-Jin Li & Shuo Wang & Shu-Cheng Wan & Jianwei Sun & Ryan T. K. Kwok & Jacky W. Y. Lam & Hexiang Deng & Ben Zhong Tang & Zhi-Jun Sun, 2023. "Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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