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Accelerated biological aging in COVID-19 patients

Author

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  • Xue Cao

    (Guizhou Provincial People’s Hospital
    Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University
    The Sixth Affiliated Hospital, Sun Yat-sen University)

  • Wenjuan Li

    (The Third Affiliated Hospital, Sun Yat-sen University)

  • Ting Wang

    (Thermo Fisher Scientific Inc.)

  • Dongzhi Ran

    (College of Medicine, University of Arizona
    Chongqing Medical University)

  • Veronica Davalos

    (Josep Carreras Leukaemia Research Institute (IJC))

  • Laura Planas-Serra

    (Bellvitge Biomedical Research Institute (IDIBELL)
    Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII)

  • Aurora Pujol

    (Bellvitge Biomedical Research Institute (IDIBELL)
    Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII
    Institucio Catalana de Recerca i Estudis Avancats (ICREA))

  • Manel Esteller

    (Josep Carreras Leukaemia Research Institute (IJC)
    Institucio Catalana de Recerca i Estudis Avancats (ICREA)
    Centro de Investigación Biomédica en Red de Cancer (CIBERONC)
    School of Medicine and Health Sciences, University of Barcelona (UB))

  • Xiaolin Wang

    (Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University)

  • Huichuan Yu

    (Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University
    The Sixth Affiliated Hospital, Sun Yat-sen University)

Abstract

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual’s chronological age (r > 0.8, p

Suggested Citation

  • Xue Cao & Wenjuan Li & Ting Wang & Dongzhi Ran & Veronica Davalos & Laura Planas-Serra & Aurora Pujol & Manel Esteller & Xiaolin Wang & Huichuan Yu, 2022. "Accelerated biological aging in COVID-19 patients," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29801-8
    DOI: 10.1038/s41467-022-29801-8
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