IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28645-6.html
   My bibliography  Save this article

Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2

Author

Listed:
  • Shan Nan Chen

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Institute of Hydrobiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Zhen Gan

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Jing Hou

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Yue Cong Yang

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Lin Huang

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Bei Huang

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Jimei University)

  • Su Wang

    (Pilot National Laboratory for Marine Science and Technology (Qingdao)
    Qingdao Agricultural University)

  • Pin Nie

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Institute of Hydrobiology, Chinese Academy of Sciences
    Chinese Academy of Sciences
    Pilot National Laboratory for Marine Science and Technology (Qingdao))

Abstract

Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequences of vertebrates. The members of class II cytokine receptors, IFN-υR1 and IL-10R2, are identified as the receptor complex of IFN-υ, and are associated with IFN-υ stimulated gene expression and antiviral activity in zebrafish (Danio rerio) and African clawed frog (Xenopus laevis). IFN-υ and IFN-υR1 are separately located at unique and highly conserved loci, being distinct from all other three-type IFNs. IFN-υ and IFN-υR1 are phylogenetically clustered with class II cytokines and class II cytokine receptors, respectively. Therefore, the finding of this IFN ligand-receptor system may be considered as a type IV IFN, in addition to the currently recognized three types of IFNs in vertebrates.

Suggested Citation

  • Shan Nan Chen & Zhen Gan & Jing Hou & Yue Cong Yang & Lin Huang & Bei Huang & Su Wang & Pin Nie, 2022. "Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28645-6
    DOI: 10.1038/s41467-022-28645-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28645-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28645-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Byrappa Venkatesh & Alison P. Lee & Vydianathan Ravi & Ashish K. Maurya & Michelle M. Lian & Jeremy B. Swann & Yuko Ohta & Martin F. Flajnik & Yoichi Sutoh & Masanori Kasahara & Shawn Hoon & Vamshidha, 2014. "Elephant shark genome provides unique insights into gnathostome evolution," Nature, Nature, vol. 505(7482), pages 174-179, January.
    2. Byrappa Venkatesh & Alison P. Lee & Vydianathan Ravi & Ashish K. Maurya & Michelle M. Lian & Jeremy B. Swann & Yuko Ohta & Martin F. Flajnik & Yoichi Sutoh & Masanori Kasahara & Shawn Hoon & Vamshidha, 2014. "Correction: Corrigendum: Elephant shark genome provides unique insights into gnathostome evolution," Nature, Nature, vol. 513(7519), pages 574-574, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yuuki Y. Watanabe & Nicholas L. Payne, 2023. "Thermal sensitivity of metabolic rate mirrors biogeographic differences between teleosts and elasmobranchs," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Anthony K. Redmond & Dearbhaile Casey & Manu Kumar Gundappa & Daniel J. Macqueen & Aoife McLysaght, 2023. "Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28645-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.